Hae Sang Lee1, Jin Soon Hwang2. 1. Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, Korea. 2. Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, Korea. pedhwnag@ajou.ac.kr.
Abstract
PURPOSE OF REVIEW: This review focuses on the complex interactions between hyperglycemia and bone fragility and the effects of antidiabetic medications on bone metabolism. RECENT FINDINGS: Type 2 diabetes (T2D) is associated with increased risk of bone fracture even in those with increased or normal bone mineral density (BMD). The pathophysiology of diabetic bone disease is not completely understood, but it is thought to be multifactorial and associated with complex cross talk among factors such as AGEs, IGF-1, enteric hormones, and pro-inflammatory cytokines. Treatment for T2D may have an impact on bone metabolism. Diabetic bone disease should be considered a serious complication of long-standing T2D.
PURPOSE OF REVIEW: This review focuses on the complex interactions between hyperglycemia and bone fragility and the effects of antidiabetic medications on bone metabolism. RECENT FINDINGS: Type 2 diabetes (T2D) is associated with increased risk of bone fracture even in those with increased or normal bone mineral density (BMD). The pathophysiology of diabetic bone disease is not completely understood, but it is thought to be multifactorial and associated with complex cross talk among factors such as AGEs, IGF-1, enteric hormones, and pro-inflammatory cytokines. Treatment for T2D may have an impact on bone metabolism. Diabetic bone disease should be considered a serious complication of long-standing T2D.
Entities:
Keywords:
Bone remodeling; Fracture; Osteoporosis; Type 2 diabetes
Authors: Elsa S Strotmeyer; Jane A Cauley; Ann V Schwartz; Michael C Nevitt; Helaine E Resnick; Douglas C Bauer; Frances A Tylavsky; Nathalie de Rekeneire; Tamara B Harris; Anne B Newman Journal: Arch Intern Med Date: 2005-07-25
Authors: Pouya Saeedi; Inga Petersohn; Paraskevi Salpea; Belma Malanda; Suvi Karuranga; Nigel Unwin; Stephen Colagiuri; Leonor Guariguata; Ayesha A Motala; Katherine Ogurtsova; Jonathan E Shaw; Dominic Bright; Rhys Williams Journal: Diabetes Res Clin Pract Date: 2019-09-10 Impact factor: 5.602
Authors: I I de Liefde; M van der Klift; C E D H de Laet; P L A van Daele; A Hofman; H A P Pols Journal: Osteoporos Int Date: 2005-06-07 Impact factor: 4.507
Authors: Nicola Napoli; Manju Chandran; Dominique D Pierroz; Bo Abrahamsen; Ann V Schwartz; Serge L Ferrari Journal: Nat Rev Endocrinol Date: 2016-09-23 Impact factor: 43.330