Literature DB >> 33241108

BBOX1 promotes triple-negative breast cancer progression by controlling IP3R3 stability.

Chengheng Liao1, Qing Zhang1.   

Abstract

Limited therapeutic options impede the clinical outcome of triple-negative breast cancer (TNBC). Our recent study uncovered a novel signaling pathway implicating gamma-butyrobetaine hydroxylase 1 (BBOX1) in the control of cell growth in TNBC, via inositol 1, 4, 5-trisphosphate receptor type 3 (IP3R3) mediated calcium signaling which is essential for cellular energy metabolism.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  2-OG dependent enzyme; TNBC; therapeutic target

Year:  2020        PMID： 33241108      PMCID： PMC7671063          DOI： 10.1080/23723556.2020.1813526

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Genetics: Intratumour heterogeneity - a game of snakes and ladders.

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Journal:  Nat Rev Clin Oncol       Date:  2015-12-15       Impact factor: 66.675

Review 2.  Ca2+ Fluxes and Cancer.

Authors:  Saverio Marchi; Carlotta Giorgi; Lorenzo Galluzzi; Paolo Pinton
Journal:  Mol Cell       Date:  2020-06-18       Impact factor: 17.970

3.  3-(2,2,2-Trimethylhydrazinium)propionate (THP)--a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties.

Authors:  B Z Simkhovich; Z V Shutenko; D V Meirena; K B Khagi; R J Mezapuķe; T N Molodchina; I J Kalviņs; E Lukevics
Journal:  Biochem Pharmacol       Date:  1988-01-15       Impact factor: 5.858

4.  Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

Authors:  César Cárdenas; Russell A Miller; Ian Smith; Thi Bui; Jordi Molgó; Marioly Müller; Horia Vais; King-Ho Cheung; Jun Yang; Ian Parker; Craig B Thompson; Morris J Birnbaum; Kenneth R Hallows; J Kevin Foskett
Journal:  Cell       Date:  2010-07-23       Impact factor: 41.582

Review 5.  Carnitine--metabolism and functions.

Authors:  J Bremer
Journal:  Physiol Rev       Date:  1983-10       Impact factor: 37.312

6.  Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

Authors:  Pawan Gulati; Lawrence D Gaspers; Stephen G Dann; Manel Joaquin; Takahiro Nobukuni; Francois Natt; Sara C Kozma; Andrew P Thomas; George Thomas
Journal:  Cell Metab       Date:  2008-05       Impact factor: 27.287

Review 7.  Type 3 inositol 1,4,5-trisphosphate receptor: A calcium channel for all seasons.

Authors:  Anjali Mangla; Mateus T Guerra; Michael H Nathanson
Journal:  Cell Calcium       Date:  2019-11-25       Impact factor: 6.817

Review 8.  Understanding the Oxygen-Sensing Pathway and Its Therapeutic Implications in Diseases.

Authors:  Chengheng Liao; Qing Zhang
Journal:  Am J Pathol       Date:  2020-04-24       Impact factor: 4.307

Review 9.  2-Oxoglutarate-Dependent Oxygenases.

Authors:  Md Saiful Islam; Thomas M Leissing; Rasheduzzaman Chowdhury; Richard J Hopkinson; Christopher J Schofield
Journal:  Annu Rev Biochem       Date:  2018-03-01       Impact factor: 23.643
  9 in total
  1 in total

1.  Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer.

Authors:  Jodi M Saunus; Xavier M De Luca; Korinne Northwood; Ashwini Raghavendra; Alexander Hasson; Amy E McCart Reed; Malcolm Lim; Samir Lal; A Cristina Vargas; Jamie R Kutasovic; Andrew J Dalley; Mariska Miranda; Emarene Kalaw; Priyakshi Kalita-de Croft; Irma Gresshoff; Fares Al-Ejeh; Julia M W Gee; Chris Ormandy; Kum Kum Khanna; Jonathan Beesley; Georgia Chenevix-Trench; Andrew R Green; Emad A Rakha; Ian O Ellis; Dan V Nicolau; Peter T Simpson; Sunil R Lakhani
Journal:  NPJ Breast Cancer       Date:  2022-05-02
  1 in total

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