Literature DB >> 33241107

Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage.

Toshimichi Yamada1, Xiaoning Sun2, Nobuyoshi Akimitsu3.   

Abstract

Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs. Further analysis revealed that cells respond to DNA damage by inhibiting PUM1-mediated mRNA decay to activate translesion synthesis (46/50).
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Pumilio; RNA stability; RNA-seq; translesion synthesis

Year:  2020        PMID： 33241107      PMCID： PMC7671024          DOI： 10.1080/23723556.2020.1812868

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

1.  RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Authors:  Carsten Hoege; Boris Pfander; George-Lucian Moldovan; George Pyrowolakis; Stefan Jentsch
Journal:  Nature       Date:  2002-09-12       Impact factor: 49.962

2.  Regulation of translesion synthesis DNA polymerase eta by monoubiquitination.

Authors:  Marzena Bienko; Catherine M Green; Simone Sabbioneda; Nicola Crosetto; Ivan Matic; Richard G Hibbert; Tihana Begovic; Atsuko Niimi; Matthias Mann; Alan R Lehmann; Ivan Dikic
Journal:  Mol Cell       Date:  2010-02-12       Impact factor: 17.970

3.  PUM1 promotes ovarian cancer proliferation, migration and invasion.

Authors:  Xue Guan; Shuo Chen; Yao Liu; Li-Li Wang; Yang Zhao; Zhi-Hong Zong
Journal:  Biochem Biophys Res Commun       Date:  2018-02-08       Impact factor: 3.575

Review 4.  Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins.

Authors:  Aaron C Goldstrohm; Traci M Tanaka Hall; Katherine M McKenney
Journal:  Trends Genet       Date:  2018-10-10       Impact factor: 11.639

5.  Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs.

Authors:  Matthew A Sanders; Brittany Haynes; Pratima Nangia-Makker; Lisa A Polin; Malathy P Shekhar
Journal:  J Biol Chem       Date:  2017-05-10       Impact factor: 5.157

6.  Systematic Analysis of Targets of Pumilio-Mediated mRNA Decay Reveals that PUM1 Repression by DNA Damage Activates Translesion Synthesis.

Authors:  Toshimichi Yamada; Naoto Imamachi; Katsutoshi Imamura; Kenzui Taniue; Takeshi Kawamura; Yutaka Suzuki; Masami Nagahama; Nobuyoshi Akimitsu
Journal:  Cell Rep       Date:  2020-05-05       Impact factor: 9.423

7.  Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals.

Authors:  Hidenori Tani; Rena Mizutani; Kazi Abdus Salam; Keiko Tano; Kenichi Ijiri; Ai Wakamatsu; Takao Isogai; Yutaka Suzuki; Nobuyoshi Akimitsu
Journal:  Genome Res       Date:  2012-02-27       Impact factor: 9.043
  7 in total

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