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Literature DB >> 33239404

The Neuroimmunology of Chronic Pain: From Rodents to Humans.

Peter M Grace¹, Vivianne L Tawfik², Camilla I Svensson³, Michael D Burton⁴, Marco L Loggia⁵, Mark R Hutchinson⁶.

Abstract

Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in rodent models of chronic pain. We further discuss new technological developments to study, diagnose, and quantify neuroimmune contributions to chronic pain in patient populations.

Entities: Chemical

Keywords: Fc gamma receptors; Nrf2; TSPO; biomarkers; cannabinoids; sex differences

Mesh：

Substances：

Year: 2020 PMID： 33239404 PMCID： PMC7880288 DOI： 10.1523/JNEUROSCI.1650-20.2020

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

141 in total

1. Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies.

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Journal: Arthritis Rheum Date: 1986-03

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Journal: Nat Rev Drug Discov Date: 2010-12 Impact factor: 84.694

4. Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons.

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Journal: J Neurosci Date: 2012-07-11 Impact factor: 6.167

Review 5. The case for peripheral CB₁ receptor blockade in the treatment of visceral obesity and its cardiometabolic complications.

Authors: George Kunos; Joseph Tam
Journal: Br J Pharmacol Date: 2011-08 Impact factor: 8.739

6. Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes.

Authors: Kutty Selva Nandakumar; Lars Svensson; Rikard Holmdahl
Journal: Am J Pathol Date: 2003-11 Impact factor: 4.307

7. Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis.

Authors: Hayley Hernstadt; Shuxing Wang; Grewo Lim; Jianren Mao
Journal: Brain Res Date: 2009-06-23 Impact factor: 3.252

8. Integrated magnetic resonance imaging and [¹¹ C]-PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis.

Authors: Mohamad J Alshikho; Nicole R Zürcher; Marco L Loggia; Paul Cernasov; Beverly Reynolds; Olivia Pijanowski; Daniel B Chonde; David Izquierdo Garcia; Caterina Mainero; Ciprian Catana; James Chan; Suma Babu; Sabrina Paganoni; Jacob M Hooker; Nazem Atassi
Journal: Ann Neurol Date: 2018-06 Impact factor: 10.422

9. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients.

Authors: Andrew David Beswick; Vikki Wylde; Rachael Gooberman-Hill; Ashley Blom; Paul Dieppe
Journal: BMJ Open Date: 2012-02-22 Impact factor: 2.692

10. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.

Authors: R B Banati; J Newcombe; R N Gunn; A Cagnin; F Turkheimer; F Heppner; G Price; F Wegner; G Giovannoni; D H Miller; G D Perkin; T Smith; A K Hewson; G Bydder; G W Kreutzberg; T Jones; M L Cuzner; R Myers
Journal: Brain Date: 2000-11 Impact factor: 13.501

21 in total

1. The PPARγ agonist pioglitazone produces a female-predominant inhibition of hyperalgesia associated with surgical incision, peripheral nerve injury, and painful diabetic neuropathy.

Authors: D F S Santos; R R Donahue; D E Laird; M C G Oliveira; B K Taylor
Journal: Neuropharmacology Date: 2021-11-29 Impact factor: 5.250

Review 2. Approach to Diagnosis and Management of Chronic Pelvic Pain in Women: Incorporating Chronic Overlapping Pain Conditions in Assessment and Management.

Authors: Sara R Till; Reina Nakamura; Andrew Schrepf; Sawsan As-Sanie
Journal: Obstet Gynecol Clin North Am Date: 2022-06 Impact factor: 2.838

3. Utilizing multiphoton imaging and integrative clearing to reveal sex differences in neuroimmune interactions after nerve injury.

Authors: Zachary W Castillo; Michael D Burton
Journal: Neural Regen Res Date: 2022-11 Impact factor: 6.058

4. Gray Matter Volume Abnormality in Chronic Pain Patients With Depressive Symptoms: A Systemic Review and Meta-Analysis of Voxel-Based Morphometry Studies.

Authors: Teng Ma; Yuan-Yuan Ji; Lin-Feng Yan; Jia-Ji Lin; Ze-Yang Li; Wen Wang; Jin-Lian Li; Guang-Bin Cui
Journal: Front Neurosci Date: 2022-06-06 Impact factor: 5.152

5. Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2-related factor 2 antioxidant signaling in rats.

Authors: Suzanne M Green-Fulgham; Michael E Harland; Jayson B Ball; Jiahe Li; Michael J Lacagnina; Heather D'Angelo; Renee A Dreher; Kendal F Willcox; Sabina A Lorca; Andrew J Kwilasz; Steven F Maier; Linda R Watkins; Peter M Grace
Journal: Pain Date: 2022-01-24 Impact factor: 7.926