Approaches to inferring multi-regional interactions from simultaneous population recordings: Inferring multi-regional interactions from simultaneous population recordings.

Most past studies of neural representations and dynamics have focused on recordings from single brain areas. However, growing evidence of brain-wide, parallel representations of cognitive variables suggests that analyzing neural representations and dynamics in individual brain areas can benefit from understanding the context of multi-regional interactions that support them. Moreover, perturbation experiments revealed that the manner in which these parallel representations interact with each other can differ dramatically across different pairs of brain areas. Recent advances in recording technology offer a potentially powerful substrate to study how multi-regional interactions coordinate neural representations in individual brain areas and dictate behavior on a single-trial basis through simultaneous recordings of multiple brain areas. We review pragmatic approaches to studying multi-regional interactions and illustrate them in the concrete context of a rodent delayed response task paradigm.