| Literature DB >> 33227504 |
Zhihong Yang1, Ting Zhang2, Sen Han2, Praveen Kusumanchi2, Nazmul Huda2, Yanchao Jiang2, Suthat Liangpunsakul3.
Abstract
The liver is a vital organ that controls glucose and lipid metabolism, hormone regulation, and bile secretion. Liver injury can occur from various insults such as viruses, metabolic diseases, and alcohol, which lead to acute and chronic liver diseases. Recent studies have demonstrated the implications of long noncoding RNAs (lncRNAs) in the pathogenesis of liver diseases. These newly discovered lncRNAs have various functions attributing to many cellular biological processes via distinct and diverse mechanisms. LncRNA H19, one of the first lncRNAs being identified, is highly expressed in fetal liver but not in adult normal liver. Its expression, however, is increased in liver diseases with various etiologies. In this review, we focused on the roles of H19 in the pathogenesis of liver diseases. This comprehensive review is aimed to provide useful perspectives and translational applications of H19 as a potential therapeutic target of liver diseases.Entities:
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Year: 2020 PMID： 33227504 PMCID： PMC9330166 DOI： 10.1016/j.trsl.2020.11.010
Source DB: PubMed Journal: Transl Res ISSN： 1878-1810 Impact factor: 10.171