Literature DB >> 22655688

Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2.

Niroshika Keppetipola1, Shalini Sharma, Qin Li, Douglas L Black.   

Abstract

Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.

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Year:  2012        PMID： 22655688      PMCID： PMC3422667          DOI： 10.3109/10409238.2012.691456

Source DB:  PubMed          Journal:  Crit Rev Biochem Mol Biol        ISSN： 1040-9238            Impact factor:   8.250


  162 in total

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Review 3.  Functional consequences of developmentally regulated alternative splicing.

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Journal:  Genes Dev       Date:  2011-02-15       Impact factor: 11.361

6.  Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells.

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Review 8.  The role of PTB in insulin mRNA stability control.

Authors:  Rickard G Fred; Linda Tillmar; Nils Welsh
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10.  The dynamic organization of the perinucleolar compartment in the cell nucleus.

Authors:  S Huang; T J Deerinck; M H Ellisman; D L Spector
Journal:  J Cell Biol       Date:  1997-06-02       Impact factor: 10.539
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  90 in total

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Review 4.  Poison exons in neurodevelopment and disease.

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7.  Prenatal arsenic exposure alters REST/NRSF and microRNA regulators of embryonic neural stem cell fate in a sex-dependent manner.

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Journal:  Neurotoxicol Teratol       Date:  2016-10-14       Impact factor: 3.763

8.  A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart.

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9.  Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

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10.  5'-UTR SNP of FGF13 causes translational defect and intellectual disability.

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