Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Rebellious autophagy proteins bypass ATG8 lipidation, taking their own path to autophagic degradation.

Literature DB >> 33226132

Rebellious autophagy proteins bypass ATG8 lipidation, taking their own path to autophagic degradation.

Abstract

LC3/GABARAP (hereafter ATG8) conjugation machineries have long been thought to play an essential role in autophagy by driving ATG8 lipidation on autophagosomal membranes. In this issue, Ohnstad et al (2020) describe an ATG8 lipidation bypass pathway which governs autophagy-dependent turnover of NBR1, highlighting that there is more than one road to autophagic degradation.

Entities: Chemical

Mesh：

Substances：

Year: 2020 PMID： 33226132 PMCID： PMC7737604 DOI： 10.15252/embj.2020106990

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 14.012

12 in total

1. The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

Authors: Kotaro Tsuboyama; Ikuko Koyama-Honda; Yuriko Sakamaki; Masato Koike; Hideaki Morishita; Noboru Mizushima
Journal: Science Date: 2016-10-20 Impact factor: 47.728

2. Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux.

Authors: Laura Pontano Vaites; Joao A Paulo; Edward L Huttlin; J Wade Harper
Journal: Mol Cell Biol Date: 2017-12-13 Impact factor: 4.272

Rebellious autophagy proteins bypass ATG8 lipidation, taking their own path to autophagic degradation.

1. The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

2. Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux.

3. Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.

4. The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.

5. Discovery of Atg5/Atg7-independent alternative macroautophagy.

6. Rebellious autophagy proteins bypass ATG8 lipidation, taking their own path to autophagic degradation.

7. The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria.

8. CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor.

9. Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.

10. Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

1. Rebellious autophagy proteins bypass ATG8 lipidation, taking their own path to autophagic degradation.