Georgina Fröhlich1, Norbert Mészáros2, Viktor Smanykó3, Gábor Stelczer3, András Herein3, Csaba Polgár2, Tibor Major2. 1. National Institute of Oncology, Centre of Radiotherapy, Budapest, Hungary; Department of Biophysics, Eötvös Loránd University, Faculty of Science, Budapest, Hungary. Electronic address: frohlich.georgina@gmail.com. 2. National Institute of Oncology, Centre of Radiotherapy, Budapest, Hungary; Department of Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary. 3. National Institute of Oncology, Centre of Radiotherapy, Budapest, Hungary.
Abstract
OBJECTIVE: To compare dosimetrically the stereotactic CyberKnife (CK) therapy and multicatheter high-dose-rate (HDR) brachytherapy (BT) for accelerated partial breast irradiation (APBI). METHODS: Treatment plans of 25 patients treated with CK were selected, and additional plans using multicatheter HDR BT were created on the same CT images. The prescribed dose was 6.25/25 Gy in both plans to the target volume (PTV). The dose-volume parameters were calculated for both techniques and compared. RESULTS: The D90 total dose of the PTV was significantly lower with CK than with HDR BT, D90 was 25.7 Gy, and 27.0 Gy (p < 0.001). However, CK plans were more conformal than BT, COIN was 0.87, and 0.81 (p = 0.0030). The V50 of the non-target breast was higher with CK than with BT: 10.5% and 3.3% (p = 0.0010), while there was no difference in the dose of the contralateral breast and contralateral lung. Dose to skin, ipsilateral lung, and ribs were higher with CK than with BT: D1 was 20.6 Gy vs. 11.5 Gy (p = 0.0018) to skin, 11.4 Gy vs. 9.6 Gy (p = 0.0272) to ipsilateral lung and 18.5 Gy vs. 12.3 Gy (p = 0.0013) to ribs, while D0.1 to heart was lower, 3.0 Gy vs. 3.2 Gy (p = 0.0476), respectively. CONCLUSIONS: Multicatheter HDR BT yields more advantageous plans than stereotactic CyberKnife treatment in accelerated partial breast irradiation, except in terms of dose conformality and the dose to the heart. There was no difference in the dose of the contralateral breast and lung.
OBJECTIVE: To compare dosimetrically the stereotactic CyberKnife (CK) therapy and multicatheter high-dose-rate (HDR) brachytherapy (BT) for accelerated partial breast irradiation (APBI). METHODS: Treatment plans of 25 patients treated with CK were selected, and additional plans using multicatheter HDR BT were created on the same CT images. The prescribed dose was 6.25/25 Gy in both plans to the target volume (PTV). The dose-volume parameters were calculated for both techniques and compared. RESULTS: The D90 total dose of the PTV was significantly lower with CK than with HDR BT, D90 was 25.7 Gy, and 27.0 Gy (p < 0.001). However, CK plans were more conformal than BT, COIN was 0.87, and 0.81 (p = 0.0030). The V50 of the non-target breast was higher with CK than with BT: 10.5% and 3.3% (p = 0.0010), while there was no difference in the dose of the contralateral breast and contralateral lung. Dose to skin, ipsilateral lung, and ribs were higher with CK than with BT: D1 was 20.6 Gy vs. 11.5 Gy (p = 0.0018) to skin, 11.4 Gy vs. 9.6 Gy (p = 0.0272) to ipsilateral lung and 18.5 Gy vs. 12.3 Gy (p = 0.0013) to ribs, while D0.1 to heart was lower, 3.0 Gy vs. 3.2 Gy (p = 0.0476), respectively. CONCLUSIONS: Multicatheter HDR BT yields more advantageous plans than stereotactic CyberKnife treatment in accelerated partial breast irradiation, except in terms of dose conformality and the dose to the heart. There was no difference in the dose of the contralateral breast and lung.
Authors: András Herein; Gábor Stelczer; Csilla Pesznyák; Georgina Fröhlich; Viktor Smanykó; Norbert Mészáros; Csaba Polgár; Tibor Major Journal: Radiol Oncol Date: 2021-03-25 Impact factor: 2.991
Authors: András Herein; Gábor Stelczer; Csilla Pesznyák; Georgina Fröhlich; Viktor Smanykó; Norbert Mészáros; Csaba Polgár; Zoltán Takácsi-Nagy; Tibor Major Journal: Rep Pract Oncol Radiother Date: 2022-03-22