Literature DB >> 33214287

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.

Ryan S Roark1, Hui Li1, Wilton B Williams2,3, Hema Chug4, Rosemarie D Mason5, Jason Gorman5, Shuyi Wang1, Fang-Hua Lee1, Juliette Rando1, Mattia Bonsignori2,3, Kwan-Ki Hwang2, Kevin O Saunders2,6, Kevin Wiehe2,3, M Anthony Moody2,7, Peter T Hraber8, Kshitij Wagh8, Elena E Giorgi8, Ronnie M Russell1, Frederic Bibollet-Ruche1, Weimin Liu1, Jesse Connell1, Andrew G Smith1, Julia DeVoto1, Alexander I Murphy1, Jessica Smith1, Wenge Ding1, Chengyan Zhao1, Neha Chohan1, Maho Okumura1, Christina Rosario1, Yu Ding1, Emily Lindemuth1, Anya M Bauer1, Katharine J Bar1, David Ambrozak5, Cara W Chao5, Gwo-Yu Chuang5, Hui Geng5, Bob C Lin5, Mark K Louder5, Richard Nguyen5, Baoshan Zhang5, Mark G Lewis9, Donald D Raymond4, Nicole A Doria-Rose5, Chaim A Schramm5, Daniel C Douek5, Mario Roederer5, Thomas B Kepler10,11, Garnett Kelsoe2,6, John R Mascola5, Peter D Kwong5, Bette T Korber8, Stephen C Harrison4,12, Barton F Haynes2,3, Beatrice H Hahn1, George M Shaw13.   

Abstract

Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural, and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertions, and deletions leading to virus persistence. The structure of one rhesus antibody, capable of neutralizing 49% of a 208-strain panel, revealed a V2 apex mode of recognition like that of human broadly neutralizing antibodies (bNAbs) PGT145 and PCT64-35S. Another rhesus antibody bound the CD4 binding site by CD4 mimicry, mirroring human bNAbs 8ANC131, CH235, and VRC01. Virus-antibody coevolution in macaques can thus recapitulate developmental features of human bNAbs, thereby guiding HIV-1 immunogen design.
Copyright © 2021, American Association for the Advancement of Science.

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Year:  2020        PMID： 33214287      PMCID： PMC8040783          DOI： 10.1126/science.abd2638

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  132 in total

1.  MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes.

Authors:  Ian W Davis; Laura Weston Murray; Jane S Richardson; David C Richardson
Journal:  Nucleic Acids Res       Date:  2004-07-01       Impact factor: 16.971

2.  Constraints on HIV-1 diversity from protein structure.

Authors:  Jeongmin Woo; David L Robertson; Simon C Lovell
Journal:  J Virol       Date:  2010-09-29       Impact factor: 5.103

3.  Induction of antibodies in guinea pigs and rhesus monkeys against the human immunodeficiency virus type 1 envelope: neutralization of nonpathogenic and pathogenic primary isolate simian/human immunodeficiency virus strains.

Authors:  H X Liao; B Etemad-Moghadam; D C Montefiori; Y Sun; J Sodroski; R M Scearce; R W Doms; J R Thomasch; S Robinson; N L Letvin; B F Haynes
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

4.  Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles.

Authors:  Miroslaw K Gorny; Leonidas Stamatatos; Barbara Volsky; Kathy Revesz; Constance Williams; Xiao-Hong Wang; Sandra Cohen; Robert Staudinger; Susan Zolla-Pazner
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

5.  Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand.

Authors:  Merlin L Robb; Leigh A Eller; Hannah Kibuuka; Kathleen Rono; Lucas Maganga; Sorachai Nitayaphan; Eugene Kroon; Fred K Sawe; Samuel Sinei; Somchai Sriplienchan; Linda L Jagodzinski; Jennifer Malia; Mark Manak; Mark S de Souza; Sodsai Tovanabutra; Eric Sanders-Buell; Morgane Rolland; Julie Dorsey-Spitz; Michael A Eller; Mark Milazzo; Qun Li; Andrew Lewandowski; Hao Wu; Edith Swann; Robert J O'Connell; Sheila Peel; Peter Dawson; Jerome H Kim; Nelson L Michael
Journal:  N Engl J Med       Date:  2016-05-18       Impact factor: 91.245

6.  Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas.

Authors:  Hannah J Barbian; Julie M Decker; Frederic Bibollet-Ruche; Rachel P Galimidi; Anthony P West; Gerald H Learn; Nicholas F Parrish; Shilpa S Iyer; Yingying Li; Craig S Pace; Ruijiang Song; Yaoxing Huang; Thomas N Denny; Hugo Mouquet; Loic Martin; Priyamvada Acharya; Baoshan Zhang; Peter D Kwong; John R Mascola; C Theo Verrips; Nika M Strokappe; Lucy Rutten; Laura E McCoy; Robin A Weiss; Corrine S Brown; Raven Jackson; Guido Silvestri; Mark Connors; Dennis R Burton; George M Shaw; Michel C Nussenzweig; Pamela J Bjorkman; David D Ho; Michael Farzan; Beatrice H Hahn
Journal:  MBio       Date:  2015-04-21       Impact factor: 7.867

7.  Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies.

Authors:  Akshaya Ramesh; Sam Darko; Axin Hua; Glenn Overman; Amy Ransier; Joseph R Francica; Ashley Trama; Georgia D Tomaras; Barton F Haynes; Daniel C Douek; Thomas B Kepler
Journal:  Front Immunol       Date:  2017-10-27       Impact factor: 8.786

8.  Improvement of antibody functionality by structure-guided paratope engraftment.

Authors:  Qingbo Liu; Yen-Ting Lai; Peng Zhang; Mark K Louder; Amarendra Pegu; Reda Rawi; Mangaiarkarasi Asokan; Xuejun Chen; Chen-Hsiang Shen; Gwo-Yu Chuang; Eun Sung Yang; Huiyi Miao; Yuge Wang; Anthony S Fauci; Peter D Kwong; John R Mascola; Paolo Lusso
Journal:  Nat Commun       Date:  2019-02-13       Impact factor: 14.919

9.  EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.

Authors:  Benjamin A Barad; Nathaniel Echols; Ray Yu-Ruei Wang; Yifan Cheng; Frank DiMaio; Paul D Adams; James S Fraser
Journal:  Nat Methods       Date:  2015-08-17       Impact factor: 28.547

10.  Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants.

Authors:  Peter Hraber; Bette Korber; Kshitij Wagh; Elena E Giorgi; Tanmoy Bhattacharya; S Gnanakaran; Alan S Lapedes; Gerald H Learn; Edward F Kreider; Yingying Li; George M Shaw; Beatrice H Hahn; David C Montefiori; S Munir Alam; Mattia Bonsignori; M Anthony Moody; Hua-Xin Liao; Feng Gao; Barton F Haynes
Journal:  Viruses       Date:  2015-10-21       Impact factor: 5.048
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  18 in total

1.  A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.

Authors:  Sarah Welbourn; Srirupa Chakraborty; Jie E Yang; Anne S Gleinich; Sailaja Gangadhara; Salar Khan; Courtney Ferrebee; Bhrugu Yagnik; Samantha Burton; Tysheena Charles; S Abigail Smith; Danielle Williams; Rohini Mopuri; Amit A Upadhyay; Justin Thompson; Matt A Price; Shiyu Wang; Zhaohui Qin; Xiaoying Shen; LaTonya D Williams; Nathan Eisel; Tiffany Peters; Lu Zhang; William Kilembe; Etienne Karita; Georgia D Tomaras; Steven E Bosinger; Rama R Amara; Parastoo Azadi; Elizabeth R Wright; Sandrasegaram Gnanakaran; Cynthia A Derdeyn
Journal:  PLoS Pathog       Date:  2022-05-03       Impact factor: 6.823

Review 2.  Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination.

Authors:  Zekun Mu; Barton F Haynes; Derek W Cain
Journal:  Curr Opin Virol       Date:  2021-11-04       Impact factor: 7.121

3.  Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env.

Authors:  Amelia Escolano; Harry B Gristick; Rajeev Gautam; Andrew T DeLaitsch; Morgan E Abernathy; Zhi Yang; Haoqing Wang; Magnus A G Hoffmann; Yoshiaki Nishimura; Zijun Wang; Nicholas Koranda; Leesa M Kakutani; Han Gao; Priyanthi N P Gnanapragasam; Henna Raina; Ana Gazumyan; Melissa Cipolla; Thiago Y Oliveira; Victor Ramos; Darrell J Irvine; Murillo Silva; Anthony P West; Jennifer R Keeffe; Christopher O Barnes; Michael S Seaman; Michel C Nussenzweig; Malcolm A Martin; Pamela J Bjorkman
Journal:  Sci Transl Med       Date:  2021-11-24       Impact factor: 19.319

4.  Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.

Authors:  Wilton B Williams; R Ryan Meyerhoff; R J Edwards; Hui Li; Kartik Manne; Nathan I Nicely; Rory Henderson; Ye Zhou; Katarzyna Janowska; Katayoun Mansouri; Sophie Gobeil; Tyler Evangelous; Bhavna Hora; Madison Berry; A Yousef Abuahmad; Jordan Sprenz; Margaret Deyton; Victoria Stalls; Megan Kopp; Allen L Hsu; Mario J Borgnia; Guillaume B E Stewart-Jones; Matthew S Lee; Naomi Bronkema; M Anthony Moody; Kevin Wiehe; Todd Bradley; S Munir Alam; Robert J Parks; Andrew Foulger; Thomas Oguin; Gregory D Sempowski; Mattia Bonsignori; Celia C LaBranche; David C Montefiori; Michael Seaman; Sampa Santra; John Perfect; Joseph R Francica; Geoffrey M Lynn; Baptiste Aussedat; William E Walkowicz; Richard Laga; Garnett Kelsoe; Kevin O Saunders; Daniela Fera; Peter D Kwong; Robert A Seder; Alberto Bartesaghi; George M Shaw; Priyamvada Acharya; Barton F Haynes
Journal:  Cell       Date:  2021-05-20       Impact factor: 41.582

5.  New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure.

Authors:  Hui Li; Shuyi Wang; Fang-Hua Lee; Ryan S Roark; Alex I Murphy; Jessica Smith; Chengyan Zhao; Juliette Rando; Neha Chohan; Yu Ding; Eunlim Kim; Emily Lindemuth; Katharine J Bar; Ivona Pandrea; Cristian Apetrei; Brandon F Keele; Jeffrey D Lifson; Mark G Lewis; Thomas N Denny; Barton F Haynes; Beatrice H Hahn; George M Shaw
Journal:  J Virol       Date:  2021-03-03       Impact factor: 5.103

Review 6.  HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens.

Authors:  Will Fischer; Elena E Giorgi; Srirupa Chakraborty; Kien Nguyen; Tanmoy Bhattacharya; James Theiler; Pablo A Goloboff; Hyejin Yoon; Werner Abfalterer; Brian T Foley; Houriiyah Tegally; James Emmanuel San; Tulio de Oliveira; Sandrasegaram Gnanakaran; Bette Korber
Journal:  Cell Host Microbe       Date:  2021-06-03       Impact factor: 31.316

Review 7.  HIV mRNA Vaccines-Progress and Future Paths.

Authors:  Zekun Mu; Barton F Haynes; Derek W Cain
Journal:  Vaccines (Basel)       Date:  2021-02-07

8.  VDJ Gene Usage in IgM Repertoires of Rhesus and Cynomolgus Macaques.

Authors:  Mark Chernyshev; Mateusz Kaduk; Martin Corcoran; Gunilla B Karlsson Hedestam
Journal:  Front Immunol       Date:  2022-01-11       Impact factor: 7.561

9.  Mind the gap from research laboratory to clinic: Challenges and opportunities for next-generation assays in human diseases.

Authors:  M Patricia D'Souza; Amy C Palin; Thomas Calder; Hana Golding; Steven H Kleinstein; Erin L Milliken; David O'Connor; Georgia Tomaras; Jon Warren; Cesar Boggiano
Journal:  Vaccine       Date:  2021-08-06       Impact factor: 4.169

Review 10.  A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target.

Authors:  Emma Parker Miller; Maxwell T Finkelstein; Molly C Erdman; Paul C Seth; Daniela Fera
Journal:  Viruses       Date:  2021-09-05       Impact factor: 5.048
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