Vira Pravosud1, Nathan L Vanderford2,3, Bin Huang4,3, Thomas C Tucker1,3, Susanne M Arnold5,3. 1. Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, Kentucky. 2. Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, Kentucky. 3. Markey Cancer Center, a National Cancer Institute Designated Cancer Center, University of Kentucky, Lexington, Kentucky. 4. Division of Cancer Biostatistics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky. 5. Division of Medical Oncology, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky.
Abstract
PURPOSE: To determine differences in exceptional survival (ES)-survival of 5 years or more past diagnosis-between stage IV non-small cell lung cancer (NSCLC) patients residing in the Appalachian versus non-Appalachian regions of Kentucky. METHODS: This was a population-based, retrospective case-control study of Kentucky patients, diagnosed with stage IV NSCLC between January 1, 2000, and December 31, 2011. The data were drawn from the Kentucky Cancer Registry. FINDINGS: Findings from the multivariable logistic regression revealed no significant differences in the odds of ES between patients who resided in Appalachian versus non-Appalachian Kentucky. Being female and undergoing surgery only as the first course of treatment were associated with higher odds of ES. Increasing age, unspecified histology, having poorly differentiated or undifferentiated carcinomas, and receiving radiation therapy only as the first course of treatment were associated with decreased odds of ES. CONCLUSION: Differences in the odds of ES among stage IV NSCLC patients were not related to residence in Appalachian versus non-Appalachian Kentucky. ES was associated with other nongenetic and treatment factors that warrant further investigations.
PURPOSE: To determine differences in exceptional survival (ES)-survival of 5 years or more past diagnosis-between stage IV non-small cell lung cancer (NSCLC) patients residing in the Appalachian versus non-Appalachian regions of Kentucky. METHODS: This was a population-based, retrospective case-control study of Kentucky patients, diagnosed with stage IV NSCLC between January 1, 2000, and December 31, 2011. The data were drawn from the Kentucky Cancer Registry. FINDINGS: Findings from the multivariable logistic regression revealed no significant differences in the odds of ES between patients who resided in Appalachian versus non-Appalachian Kentucky. Being female and undergoing surgery only as the first course of treatment were associated with higher odds of ES. Increasing age, unspecified histology, having poorly differentiated or undifferentiated carcinomas, and receiving radiation therapy only as the first course of treatment were associated with decreased odds of ES. CONCLUSION: Differences in the odds of ES among stage IV NSCLC patients were not related to residence in Appalachian versus non-Appalachian Kentucky. ES was associated with other nongenetic and treatment factors that warrant further investigations.
Authors: S C Erridge; M N Gaze; A Price; C G Kelly; G R Kerr; A Cull; R H MacDougall; G C W Howard; V J Cowie; A Gregor Journal: Clin Oncol (R Coll Radiol) Date: 2005-02 Impact factor: 4.126
Authors: E Rapp; J L Pater; A Willan; Y Cormier; N Murray; W K Evans; D I Hodson; D A Clark; R Feld; A M Arnold Journal: J Clin Oncol Date: 1988-04 Impact factor: 44.544