BACKGROUND: Colorectal neuroendocrine tumors (NETs) are the most common NETs of the gastrointestinal tract. Due to the rarity, colorectal NETs are understudied and are not clearly understood. Our study sought to identify the factors associated with worse outcomes for colorectal NETs following resection. METHODS: We identified patients diagnosed with colorectal NETs [2004-2014] who underwent resection from the National Cancer Data Base. Non-NETs were excluded. Overall survival (OS) was evaluated using the Kaplan Meier method. Cox proportional hazards and logistic regression models were used to assess factors associated with radical versus local resection, OS and LOS. RESULTS: A total of 7,967 colon and 11,929 rectal NETs were analyzed. The majority of colon (93.4%) and rectal (89.1%) NETs underwent radical and local resection respectively. The 5-year OS was 69% and 92% for colon and rectal NETs respectively. Older age (OR 1.45, CI 1.37-1.53) and clinical stage 4 (OR 9.91, CI 4.56-21.52) were associated with higher odds for colonic radical resection. Lowest median income quartile (OR 1.41, CI 1.21-1.64) and African Americans (OR 1.26, CI 1.07-1.49) experienced higher mortality for colon and rectal NETs respectively. CONCLUSIONS: Racial minority and low-income patients experience worse outcomes for colorectal NETs following resection. 2020 Journal of Gastrointestinal Oncology. All rights reserved.
BACKGROUND: Colorectal neuroendocrine tumors (NETs) are the most common NETs of the gastrointestinal tract. Due to the rarity, colorectal NETs are understudied and are not clearly understood. Our study sought to identify the factors associated with worse outcomes for colorectal NETs following resection. METHODS: We identified patients diagnosed with colorectal NETs [2004-2014] who underwent resection from the National Cancer Data Base. Non-NETs were excluded. Overall survival (OS) was evaluated using the Kaplan Meier method. Cox proportional hazards and logistic regression models were used to assess factors associated with radical versus local resection, OS and LOS. RESULTS: A total of 7,967 colon and 11,929 rectal NETs were analyzed. The majority of colon (93.4%) and rectal (89.1%) NETs underwent radical and local resection respectively. The 5-year OS was 69% and 92% for colon and rectal NETs respectively. Older age (OR 1.45, CI 1.37-1.53) and clinical stage 4 (OR 9.91, CI 4.56-21.52) were associated with higher odds for colonic radical resection. Lowest median income quartile (OR 1.41, CI 1.21-1.64) and African Americans (OR 1.26, CI 1.07-1.49) experienced higher mortality for colon and rectal NETs respectively. CONCLUSIONS: Racial minority and low-income patients experience worse outcomes for colorectal NETs following resection. 2020 Journal of Gastrointestinal Oncology. All rights reserved.
Entities:
Keywords:
National Cancer Data Base; Neuroendocrine neoplasms; colorectal cancer; endoscopic resection; neuroendocrine carcinoma (NEC); neuroendocrine tumors (NETs); outcomes; radical resection
Authors: Riad H Al Natour; Mandeep S Saund; Vivian M Sanchez; Edward E Whang; Ashish M Sharma; Qin Huang; Valia A Boosalis; Jason S Gold Journal: J Gastrointest Surg Date: 2011-12-06 Impact factor: 3.452
Authors: Ferga C Gleeson; Michael J Levy; Eric J Dozois; David W Larson; Louis Michel Wong Kee Song; Lisa A Boardman Journal: Gastrointest Endosc Date: 2014-01-23 Impact factor: 9.427
Authors: Brian Ezekian; Mohamad A Adam; Megan C Turner; Brian F Gilmore; Kyle Freischlag; Harold J Leraas; Christopher R Mantyh; John Migaly Journal: J Surg Res Date: 2018-05-14 Impact factor: 2.192
Authors: Camilla Gallo; Roberta Elisa Rossi; Federica Cavalcoli; Federico Barbaro; Ivo Boškoski; Pietro Invernizzi; Sara Massironi Journal: World J Gastroenterol Date: 2022-03-21 Impact factor: 5.742