Janine S Spitzhüttl1,2,3, Martin Kronbichler4,5, Lisa Kronbichler4,5,6, Valentin Benzing3,7, Valerie Siegwart2,3, Manuela Pastore-Wapp8, Claus Kiefer8, Nedelina Slavova8, Michael Grotzer9, Claudia M Roebers1, Maja Steinlin2, Kurt Leibundgut3, Regula Everts2,3. 1. Department of Psychology, University of Bern, Bern, Switzerland. 2. Neuropediatrics, Development and Rehabilitation, University Children's Hospital Bern, and University of Bern, Bern, Switzerland. 3. Department of Pediatric Hematology and Oncology, University Children's Hospital Bern, University of Bern, Bern, Switzerland. 4. Centre for Cognitive Neuroscience and Department of Psychology, University of Salzburg, Salzburg, Austria. 5. Neuroscience Institute, Christian-Doppler Medical Centre, Paracelsus Medical University, Salzburg, Austria. 6. Department of Psychiatry, Psychotherapy and Psychosomatics, Christian-Doppler Medical Centre, Paracelsus Medical University, Salzburg, Austria. 7. Institute of Sport Science, University of Bern, Bern, Switzerland. 8. Support Center for Advanced Neuroimaging (SCAN), Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland. 9. Department of Pediatric Oncology, University Children's Hospital Zurich, Zurich, Switzerland.
Abstract
INTRODUCTION: Non-central nervous system cancer in childhood (non-CNS CC) and its treatments pose a major threat to brain development, with implications for functional networks. Structural and functional alterations might underlie the cognitive late-effects identified in survivors of non-CNS CC. The present study evaluated resting-state functional networks and their associations with cognition in a mixed sample of non-CNS CC survivors (i.e., leukemia, lymphoma, and other non-CNS solid tumors). METHODS: Forty-three patients (off-therapy for at least 1 year and aged 7-16 years) were compared with 43 healthy controls matched for age and sex. High-resolution T1-weighted structural magnetic resonance and resting-state functional magnetic resonance imaging were acquired. Executive functions, attention, processing speed, and memory were assessed outside the scanner. RESULTS: Cognitive performance was within the normal range for both groups; however, patients after CNS-directed therapy showed lower executive functions than controls. Seed-based connectivity analyses revealed that patients exhibited stronger functional connectivity between fronto- and temporo-parietal pathways and weaker connectivity between parietal-cerebellar and temporal-occipital pathways in the right hemisphere than controls. Functional hyperconnectivity was related to weaker memory performance in the patients' group. CONCLUSION: These data suggest that even in the absence of brain tumors, non-CNS CC and its treatment can lead to persistent cerebral alterations in resting-state network connectivity.
INTRODUCTION:Non-central nervous system cancer in childhood (non-CNS CC) and its treatments pose a major threat to brain development, with implications for functional networks. Structural and functional alterations might underlie the cognitive late-effects identified in survivors of non-CNS CC. The present study evaluated resting-state functional networks and their associations with cognition in a mixed sample of non-CNS CC survivors (i.e., leukemia, lymphoma, and other non-CNS solid tumors). METHODS: Forty-three patients (off-therapy for at least 1 year and aged 7-16 years) were compared with 43 healthy controls matched for age and sex. High-resolution T1-weighted structural magnetic resonance and resting-state functional magnetic resonance imaging were acquired. Executive functions, attention, processing speed, and memory were assessed outside the scanner. RESULTS: Cognitive performance was within the normal range for both groups; however, patients after CNS-directed therapy showed lower executive functions than controls. Seed-based connectivity analyses revealed that patients exhibited stronger functional connectivity between fronto- and temporo-parietal pathways and weaker connectivity between parietal-cerebellar and temporal-occipital pathways in the right hemisphere than controls. Functional hyperconnectivity was related to weaker memory performance in the patients' group. CONCLUSION: These data suggest that even in the absence of brain tumors, non-CNS CC and its treatment can lead to persistent cerebral alterations in resting-state network connectivity.
Authors: Elizabeth R Sowell; Bradley S Peterson; Paul M Thompson; Suzanne E Welcome; Amy L Henkenius; Arthur W Toga Journal: Nat Neurosci Date: 2003-03 Impact factor: 24.884
Authors: Yin Ting Cheung; Raja B Khan; Wei Liu; Tara M Brinkman; Michelle N Edelmann; Wilburn E Reddick; Deqing Pei; Angela Panoskaltsis-Mortari; Deokumar Srivastava; Cheng Cheng; Leslie L Robison; Melissa M Hudson; Ching-Hon Pui; Kevin R Krull Journal: JAMA Oncol Date: 2018-07-12 Impact factor: 31.777
Authors: Ellen van der Plas; Brian J Nieman; Darci T Butcher; Johann K Hitzler; Rosanna Weksberg; Shinya Ito; Russell Schachar Journal: J Can Acad Child Adolesc Psychiatry Date: 2015-03-04