| Literature DB >> 33202261 |
Christian Isalomboto Nkanga1, Andreas Fisch2, Mazda Rad-Malekshahi3, Marieta Duvnjak Romic2, Birgit Kittel4, Thomas Ullrich4, Jing Wang2, Rui Werner Maçedo Krause5, Sabine Adler2, Twan Lammers6, Wim E Hennink7, Farshad Ramazani8.
Abstract
Long acting injectable formulations have been developed to sustain the action of drugs in the body over desired periods of time. These delivery platforms have been utilized for both systemic and local drug delivery applications. This review gives an overview of long acting injectable systems that are currently in clinical use. These products are categorized in three different groups: biodegradable polymeric systems, including microparticles and implants; micro and nanocrystal suspensions and oil-based formulations. Furthermore, the applications of these drug delivery platforms for the management of various chronic diseases are summarized. Finally, this review addresses industrial challenges regarding the development of long acting injectable formulations.Entities:
Keywords: Drug crystal suspensions; Drug crystals; Drug delivery; Extended release; Implants; In situ forming implants; Long acting injectables; Microspheres; Oil-based formulations; PLGA microparticles
Year: 2020 PMID： 33202261 DOI： 10.1016/j.addr.2020.11.008
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470