Literature DB >> 33199384

fosM, a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota.

Sami Khabthani1, Mouna Hamel1, Sophie Alexandra Baron1, Seydina M Diene1, Jean-Marc Rolain1, Vicky Merhej2.   

Abstract

Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined in vitro/in silico approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Escherichia coli strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named fosM.
Copyright © 2021 American Society for Microbiology.

Entities:  

Keywords:  FosM; bacillithiol transferase; fosfomycin resistance; genomes; human microbiota; phylogenetics

Mesh：

Substances：

Year:  2021        PMID： 33199384      PMCID： PMC7848996          DOI： 10.1128/AAC.01712-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

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Journal:  Antimicrob Agents Chemother       Date:  2020-03-24       Impact factor: 5.191

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10.  Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin Resistance.

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Journal:  Front Microbiol       Date:  2019-02-13       Impact factor: 5.640
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  4 in total

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4.  Whole Genome Analysis of 335 New Bacterial Species from Human Microbiota Reveals a Huge Reservoir of Transferable Antibiotic Resistance Determinants.

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  4 in total

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