BACKGROUND: The risk of COVID-19 infection in transplant recipients (TRs) is unknown. Patients on dialysis may be exposed to greater risk of infection due to an inability to isolate. Consideration of these competing risks is important before restarting suspended transplant programs. This study compared outcomes in kidney and kidney/pancreas TRs with those on the waiting list, following admission with COVID-19 in a high-prevalence region. METHODS: Audit data from all 6 London transplant centers were amalgamated. Demographic and laboratory data were collected and outcomes included mortality, intensive care (ITU) admission, and ventilation. Adult patients who had undergone a kidney or kidney/pancreas transplant, and those active on the transplant waiting list at the start of the pandemic were included. RESULTS: One hundred twenty-one TRs and 52 waiting list patients (WL) were admitted to hospital with COVID-19. Thirty-six TR died (30%), while 14 WL patients died (27% P = 0.71). There was no difference in rates of admission to ITU or ventilation. Twenty-four percent of TR required renal replacement therapy, and 12% lost their grafts. Lymphocyte nadir and D-dimer peak showed no difference in those who did and did not die. No other comorbidities or demographic factors were associated with mortality, except for age (odds ratio of 4.3 [95% CI 1.8-10.2] for mortality if aged over 60 y) in TR. CONCLUSIONS: TRs and waiting list patients have similar mortality rates after hospital admission with COVID-19. Mortality was higher in older TRs. These data should inform decisions about transplantation in the COVID era.
BACKGROUND: The risk of COVID-19infection in transplant recipients (TRs) is unknown. Patients on dialysis may be exposed to greater risk of infection due to an inability to isolate. Consideration of these competing risks is important before restarting suspended transplant programs. This study compared outcomes in kidney and kidney/pancreas TRs with those on the waiting list, following admission with COVID-19 in a high-prevalence region. METHODS: Audit data from all 6 London transplant centers were amalgamated. Demographic and laboratory data were collected and outcomes included mortality, intensive care (ITU) admission, and ventilation. Adult patients who had undergone a kidney or kidney/pancreas transplant, and those active on the transplant waiting list at the start of the pandemic were included. RESULTS: One hundred twenty-one TRs and 52 waiting list patients (WL) were admitted to hospital with COVID-19. Thirty-six TRdied (30%), while 14 WL patientsdied (27% P = 0.71). There was no difference in rates of admission to ITU or ventilation. Twenty-four percent of TR required renal replacement therapy, and 12% lost their grafts. Lymphocyte nadir and D-dimer peak showed no difference in those who did and did not die. No other comorbidities or demographic factors were associated with mortality, except for age (odds ratio of 4.3 [95% CI 1.8-10.2] for mortality if aged over 60 y) in TR. CONCLUSIONS: TRs and waiting list patients have similar mortality rates after hospital admission with COVID-19. Mortality was higher in older TRs. These data should inform decisions about transplantation in the COVID era.
Authors: Ilona Cieślak; Magdalena Kwapisz; Olga Tronina; Joanna Gotlib; Wojciech Lisik; Dariusz Wasiak; Marta Hreńczuk; Mansur Rahnama; Piotr Małkowski Journal: Ann Transplant Date: 2022-09-16 Impact factor: 1.479
Authors: Deborah A Theodore; William G Greendyke; Benjamin Miko; Susan Whittier; Daniel A Green; Sherif Shoucri; Elizabeth C Verna; Jason Zucker; Magdalena E Sobieszczyk; Justin G Aaron; Brian E Scully; Lisa Saiman; Marcus Pereira; E Yoko Furuya Journal: Transplantation Date: 2021-07-01 Impact factor: 5.385
Authors: Laura Linares; Frederic Cofan; Fritz Diekmann; Sabina Herrera; María Angeles Marcos; María Angeles Castel; Marta Farrero; Jordi Colmenero; Pablo Ruiz; Gonzalo Crespo; Jaume Llopis; Carolina Garcia-Vidal; Àlex Soriano; Asunción Moreno; Marta Bodro Journal: PLoS One Date: 2021-03-03 Impact factor: 3.240
Authors: Luke Muir; Aneesa Jaffer; Chloe Rees-Spear; Vignesh Gopalan; Fernando Y Chang; Raymond Fernando; Gintare Vaitkute; Chloe Roustan; Annachiara Rosa; Christopher Earl; Gayathri K Rajakaruna; Peter Cherepanov; Alan Salama; Laura E McCoy; Reza Motallebzadeh Journal: Kidney Int Rep Date: 2021-04-28
Authors: Refik Gökmen; Antonia Cronin; Wendy Brown; Stephen Cass; Abbas Ghazanfar; Mohammad Ayaz Hossain; Jenny Johnson; Trish Longdon; Sue Lyon; Adam McLean; Reza Motallebzadeh; Joyce Popoola; Ayo Samuel; Raj Thuraisingham; Angela-Jane Wood; Frank J M F Dor Journal: Transpl Int Date: 2021-09-19 Impact factor: 3.842