BACKGROUND: The optimal duration of transmission-based precautions among immunocompromised patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. METHODS: Retrospective review of patients with solid organ transplant with positive SARS-CoV-2 polymerase chain reaction result from nasopharyngeal specimens admitted to the hospital between March 13, 2020 and May 15, 2020. RESULTS: Twenty-one percent of solid organ transplant recipients with positive SARS-CoV-2 polymerase chain reaction detected ≥20 d after symptom onset (or after first positive test among asymptomatic individuals) had a low cycle threshold (ie, high viral load). The majority of these patients were asymptomatic or symptomatically improved. CONCLUSIONS: Solid organ transplant recipients may have prolonged high viral burden of SARS-CoV-2. Further data are needed to understand whether cycle threshold data can help inform strategies for prevention of healthcare-associated transmission of SARS-CoV-2 and for appropriate discontinuation of transmission-based precautions.
BACKGROUND: The optimal duration of transmission-based precautions among immunocompromised patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. METHODS: Retrospective review of patients with solid organ transplant with positive SARS-CoV-2 polymerase chain reaction result from nasopharyngeal specimens admitted to the hospital between March 13, 2020 and May 15, 2020. RESULTS: Twenty-one percent of solid organ transplant recipients with positive SARS-CoV-2 polymerase chain reaction detected ≥20 d after symptom onset (or after first positive test among asymptomatic individuals) had a low cycle threshold (ie, high viral load). The majority of these patients were asymptomatic or symptomatically improved. CONCLUSIONS: Solid organ transplant recipients may have prolonged high viral burden of SARS-CoV-2. Further data are needed to understand whether cycle threshold data can help inform strategies for prevention of healthcare-associated transmission of SARS-CoV-2 and for appropriate discontinuation of transmission-based precautions.
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Authors: C R A de Lima; T B Mirandolli; L C Carneiro; C Tusset; C M Romer; H F Andreolla; L F Baethgen; A C Pasqualotto Journal: Transpl Infect Dis Date: 2013-12-02 Impact factor: 2.228
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Authors: Brendan J Keating; Eyas H Mukhtar; Eric D Elftmann; Feyisope R Eweje; Hui Gao; Lina I Ibrahim; Ranganath G Kathawate; Alexander C Lee; Eric H Li; Krista A Moore; Nikhil Nair; Venkata Chaluvadi; Janaiya Reason; Francesca Zanoni; Alexander T Honkala; Amein K Al-Ali; Fatima Abdullah Alrubaish; Maha Ahmad Al-Mozaini; Fahad A Al-Muhanna; Khaldoun Al-Romaih; Samuel B Goldfarb; Ryan Kellogg; Krzysztof Kiryluk; Sarah J Kizilbash; Taisa J Kohut; Juhi Kumar; Matthew J O'Connor; Elizabeth B Rand; Robert R Redfield; Benjamin Rolnik; Joseph Rossano; Pablo G Sanchez; Arash Alavi; Amir Bahmani; Gireesh K Bogu; Andrew W Brooks; Ahmed A Metwally; Tejas Mishra; Stephen D Marks; Robert A Montgomery; Jay A Fishman; Sandra Amaral; Pamala A Jacobson; Meng Wang; Michael P Snyder Journal: Transpl Int Date: 2021-05-05 Impact factor: 3.782