Lu He1, Yanlin Li1, Guoliang Wang1, Canzhang Li1. 1. Kunming Medical University, Kunming Yunnan, 650000, P.R.China;Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650000, P.R.China.
Abstract
OBJECTIVE: To summarize the regulatory effect of long non-coding RNA (lncRNA) on osteoarthritis (OA) cartilage injury. METHODS: The molecular functions and mechanisms of lncRNA were introduced and its regulatory effects on the pathological processes of OA were elaborated by referring to the relevant literature at domestic and abroad in recent years. RESULTS: The pathological characteristics of OA are degeneration of articular cartilage and inflammation of synovial tissue, but its etiology and pathological mechanism have not been clarified. lncRNA is a kind of heterogeneous non-coding RNA, which plays a regulatory role in many inflammation-related diseases and exerts a wide range of biological functions. lncRNA is a regulator involved in the pathogenesis of OA, and is abnormally expressed in OA cartilage, leading to the degeneration of the extracellular matrix of cartilage. CONCLUSION: At present, there have been preliminary studies on the pathological effects of lncRNA in regulating OA and the biological functions of chondrocytes. However, the pathogenesis of lncRNA and its regulatory network in OA and the way in which it regulates inflammatory pathways are still unclear, and further exploration is needed.
OBJECTIVE: To summarize the regulatory effect of long non-coding RNA (lncRNA) on osteoarthritis (OA) cartilage injury. METHODS: The molecular functions and mechanisms of lncRNA were introduced and its regulatory effects on the pathological processes of OA were elaborated by referring to the relevant literature at domestic and abroad in recent years. RESULTS: The pathological characteristics of OA are degeneration of articular cartilage and inflammation of synovial tissue, but its etiology and pathological mechanism have not been clarified. lncRNA is a kind of heterogeneous non-coding RNA, which plays a regulatory role in many inflammation-related diseases and exerts a wide range of biological functions. lncRNA is a regulator involved in the pathogenesis of OA, and is abnormally expressed in OA cartilage, leading to the degeneration of the extracellular matrix of cartilage. CONCLUSION: At present, there have been preliminary studies on the pathological effects of lncRNA in regulating OA and the biological functions of chondrocytes. However, the pathogenesis of lncRNA and its regulatory network in OA and the way in which it regulates inflammatory pathways are still unclear, and further exploration is needed.
Entities:
Keywords:
Osteoarthritis; cartilage degeneration; long non-coding RNA; regulation
Authors: Ci Chu; Qiangfeng Cliff Zhang; Simão Teixeira da Rocha; Ryan A Flynn; Maheetha Bharadwaj; J Mauro Calabrese; Terry Magnuson; Edith Heard; Howard Y Chang Journal: Cell Date: 2015-04-02 Impact factor: 41.582