Carlijn L Janssen1, Annemieke S Littooij1,2, Marta Fiocco1,3,4, Josephine C B Huige1,2, Ronald R de Krijger1,5, Caroline C C Hulsker1, Angelique J Goverde6, József Zsiros1, Annelies M C Mavinkurve-Groothuis7. 1. Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands. 2. Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. 3. Mathematical Institute Leiden University, Leiden, The Netherlands. 4. Medical Statistics, Biomedical Data Science Department, Leiden University Medical Center, Leiden, The Netherlands. 5. Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. 6. Department of Reproductive Medicine and Gynaecology, University Medical Center of Utrecht, Utrecht, The Netherlands. 7. Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands. a.m.c.mavinkurve-groothuis@prinsesmaximacentrum.nl.
Abstract
BACKGROUND: The diagnostic workup of ovarian tumors in children and adolescents is challenging because preserving fertility, in addition to oncological safety, is of particular importance in this population. Therefore, a thorough preoperative assessment of ovarian tumors is required. OBJECTIVE: To investigate the diagnostic value of MR imaging in differentiating benign from malignant ovarian tumors in children and adolescents. MATERIALS AND METHODS: We conducted a retrospective study of all children and adolescents age <18 years who underwent MR imaging of ovarian tumors during 2014-2019 at a pediatric specialty center. Two radiologists reviewed all MR imaging. We used pathology reports to define the histological diagnosis. RESULTS: We included 30 girls who underwent MR imaging for an ovarian tumor. Signs indicative for malignancy were tumors with a diameter ≥8 cm, with areas of contrast enhancement, irregular margins, extracapsular tumor growth, and ascites. All benign and malignant ovarian tumors were correctly identified by the radiologists. CONCLUSION: The diagnostic utility of MR imaging in classifying ovarian tumors in children and adolescents as benign or malignant is promising and might aid in defining the indication for ovarian-sparing versus non-ovarian-sparing surgery. We recommend evaluating these tumors with MR imaging prior to deciding on surgical treatment.
BACKGROUND: The diagnostic workup of ovarian tumors in children and adolescents is challenging because preserving fertility, in addition to oncological safety, is of particular importance in this population. Therefore, a thorough preoperative assessment of ovarian tumors is required. OBJECTIVE: To investigate the diagnostic value of MR imaging in differentiating benign from malignant ovarian tumors in children and adolescents. MATERIALS AND METHODS: We conducted a retrospective study of all children and adolescents age <18 years who underwent MR imaging of ovarian tumors during 2014-2019 at a pediatric specialty center. Two radiologists reviewed all MR imaging. We used pathology reports to define the histological diagnosis. RESULTS: We included 30 girls who underwent MR imaging for an ovarian tumor. Signs indicative for malignancy were tumors with a diameter ≥8 cm, with areas of contrast enhancement, irregular margins, extracapsular tumor growth, and ascites. All benign and malignant ovarian tumors were correctly identified by the radiologists. CONCLUSION: The diagnostic utility of MR imaging in classifying ovarian tumors in children and adolescents as benign or malignant is promising and might aid in defining the indication for ovarian-sparing versus non-ovarian-sparing surgery. We recommend evaluating these tumors with MR imaging prior to deciding on surgical treatment.
Authors: Jonathan C Papic; S Maria E Finnell; James E Slaven; Deborah F Billmire; Frederick J Rescorla; Charles M Leys Journal: J Pediatr Surg Date: 2013-11-22 Impact factor: 2.545
Authors: Pietro Valerio Foti; Giancarlo Attinà; Saveria Spadola; Rosario Caltabiano; Renato Farina; Stefano Palmucci; Giuseppe Zarbo; Rosario Zarbo; Maria D'Arrigo; Pietro Milone; Giovanni Carlo Ettorre Journal: Insights Imaging Date: 2015-12-16
Authors: Lotte W E van Nimwegen; Annelies M C Mavinkurve-Groothuis; Ronald R de Krijger; Caroline C C Hulsker; Angelique J Goverde; József Zsiros; Annemieke S Littooij Journal: Eur Radiol Date: 2019-09-16 Impact factor: 5.315