Literature DB >> 3317828

Redesigning nature's poisons to create anti-tumor reagents.

E S Vitetta1, R J Fulton, R D May, M Till, J W Uhr.   

Abstract

Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

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Year:  1987        PMID： 3317828     DOI： 10.1126/science.3317828

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  48 in total

1.  Design of protein struts for self-assembling nanoconstructs.

Authors:  Paul Hyman; Regina Valluzzi; Edward Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-17       Impact factor: 11.205

2.  Infectious enveloped RNA virus antigenic chimeras.

Authors:  S D London; A L Schmaljohn; J M Dalrymple; C M Rice
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

3.  Phage display of ricin B chain and its single binding domains: system for screening galactose-binding mutants.

Authors:  C Swimmer; S M Lehar; J McCafferty; D J Chiswell; W A Blättler; B C Guild
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

4.  A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin.

Authors:  V K Chaudhary; M G Gallo; D J FitzGerald; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

Review 5.  [Tumor lectinology--status and perspectives of clinical application].

Authors:  H J Gabius; S Gabius
Journal:  Naturwissenschaften       Date:  1990-11

Review 6.  Monoclonal antibodies. Future potential in cancer chemotherapy.

Authors:  C Kosmas; H Kalofonos; A A Epenetos
Journal:  Drugs       Date:  1989-11       Impact factor: 9.546

7.  A potent and specific immunotoxin for tumor cells expressing disialoganglioside GD2.

Authors:  K Mujoo; R A Reisfeld; L Cheung; M G Rosenblum
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

8.  Disulfide linked alpha oLH-gelonin conjugate failed to recombine with beta oLH subunit to generate bioeffective hormonotoxin.

Authors:  V Singh; R Curtiss
Journal:  Mol Cell Biochem       Date:  1993-03-24       Impact factor: 3.396

9.  Immunotoxin therapy of leptomeningeal neoplasia.

Authors:  S Walbridge; S M Rybak
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

10.  Hormonotoxins: the role of positive charge of lysine residue on the immunological, biological and cytotoxic properties of ovine lutropin-S-S-gelonin conjugates.

Authors:  V Singh; R Curtiss
Journal:  Mol Cell Biochem       Date:  1994-01-12       Impact factor: 3.396
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