Literature DB >> 2074894

[Tumor lectinology--status and perspectives of clinical application].

H J Gabius1, S Gabius.   

Abstract

A detailed knowledge of the mechanisms of molecular recognition is a prerequisite to rationally improved diagnostic and therapeutic procedures in diseases. In addition to sequences of amino acids, carbohydrate structures apparently store biological information that is thought to be relevant for physiologically important processes. Such ligands, namely the carbohydrate part of cellular glycoconjugates, can be recognized by specific endogenous binding proteins like lectins. If their presence can be reliably ascertained and correlated to the clinical course of the disease, e.g. in oncology, lectinology may help to define a yet undisclosed role for this class of proteins in tumor progression and spread.

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Year:  1990        PMID: 2074894     DOI: 10.1007/BF01139261

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN: 0028-1042


  66 in total

Review 1.  Lectin cytochemistry and histochemistry.

Authors:  I Damjanov
Journal:  Lab Invest       Date:  1987-07       Impact factor: 5.662

Review 2.  Endogenous lectins in tumors and the immune system.

Authors:  H J Gabius
Journal:  Cancer Invest       Date:  1987       Impact factor: 2.176

Review 3.  Bacterial lectins: mediators of adhesion.

Authors:  G Uhlenbruck
Journal:  Zentralbl Bakteriol Mikrobiol Hyg A       Date:  1987-03

Review 4.  Lectins and blood group substances as "tumor markers".

Authors:  J Caselitz
Journal:  Curr Top Pathol       Date:  1987

Review 5.  [Endogenous lectins in tumors and their possible importance in the diagnosis and therapy of cancers].

Authors:  H J Gabius
Journal:  Onkologie       Date:  1989-08

6.  Efficient coupling of glycopeptides to proteins with a heterobifunctional reagent.

Authors:  R T Lee; T C Wong; R Lee; L Yue; Y C Lee
Journal:  Biochemistry       Date:  1989-02-21       Impact factor: 3.162

7.  Regulation of distribution, amount and ligand affinity of sugar receptors in human colon carcinoma cells by treatment with sodium butyrate, retinoic acid and phorbol ester.

Authors:  S Gabius; N Yamazaki; W Hanewacker; H J Gabius
Journal:  Anticancer Res       Date:  1990 Jul-Aug       Impact factor: 2.480

8.  Modulation of galactoside-binding lectins in tumor cells by differentiation-inducing agents.

Authors:  R Lotan; D Lotan; D M Carralero
Journal:  Cancer Lett       Date:  1989-11-30       Impact factor: 8.679

9.  Carrier-immobilized derivatized lysoganglioside GM1 is a ligand for specific binding sites in various human tumor cell types and peripheral blood lymphocytes and monocytes.

Authors:  S Gabius; K Kayser; K P Hellmann; T Ciesiolka; A Trittin; H J Gabius
Journal:  Biochem Biophys Res Commun       Date:  1990-05-31       Impact factor: 3.575

10.  Antitumor activity of recombinant interleukin 6 in mice.

Authors:  J J Mulé; J K McIntosh; D M Jablons; S A Rosenberg
Journal:  J Exp Med       Date:  1990-03-01       Impact factor: 14.307

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  3 in total

1.  Transformation-associated decrease in cell surface binding of neoglycoenzymes in a temperature-sensitive, virally transformed mouse model.

Authors:  H J Gabius; S Gabius; M Fritsche; G Brandner
Journal:  Naturwissenschaften       Date:  1991-05

2.  Behavior of lymphocyte subsets and expression of activation markers in response to immunotherapy with galactoside-specific lectin from mistletoe in breast cancer patients.

Authors:  J Beuth; H L Ko; H J Gabius; H Burrichter; K Oette; G Pulverer
Journal:  Clin Investig       Date:  1992-08

Review 3.  [Protein-carbohydrate recognition. Foundation and medical application with illustrations of tumor lectin studies].

Authors:  H J Gabius; K Kayser; S Gabius
Journal:  Naturwissenschaften       Date:  1995-12
  3 in total

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