Mahshid Safavi1, Nazila Bostanshirin1, Bahareh Hajikhani2, Somayeh Yaslianifard1, Alex van Belkum3, Mehdi Goudarzi2, Ali Hashemi2, Davood Darban-Sarokhalil4, Masoud Dadashi5. 1. Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. 2. Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Open Innovation and Partnerships, bioMérieux 3, La Balme Les Grottes, France. 4. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. 5. Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Non Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address: m_d6512@yahoo.com.
Abstract
BACKGROUND AND AIM: The global rise of antimicrobial resistance among bacterial strains is a rapidly growing challenge and is becoming a major public health concern. This study documents the worldwide spread and genotype distribution of human clinical isolates of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae (NPKP). METHODS: Several international databases, including Web of Science, Embase and Medline were searched (2010 - 2019) to identify studies addressing the frequency of NPKP regionally or worldwide. RESULTS: Of 4779 articles identified, 202 studies fulfilled the eligibility criteria and were included in our analysis. The frequency of NPKP in Asia, Europe, America, Africa and Oceania was 64.6%, 20.1%, 9.0%, 5.6% and 0.4%, respectively. The most prevalent sequence types (STs) among NPKP were ST11, ST290, ST147, ST340, ST15, ST278 and ST14 based on published studies. CONCLUSION: The dissemination of blaNDM variants in different STs among NPKP in the various region of world is a serious concern to public health. The prevalence of NPKP should be controlled by comprehensive infection control measures and optimization of antibiotic therapy.
BACKGROUND AND AIM: The global rise of antimicrobial resistance among bacterial strains is a rapidly growing challenge and is becoming a major public health concern. This study documents the worldwide spread and genotype distribution of human clinical isolates of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae (NPKP). METHODS: Several international databases, including Web of Science, Embase and Medline were searched (2010 - 2019) to identify studies addressing the frequency of NPKP regionally or worldwide. RESULTS: Of 4779 articles identified, 202 studies fulfilled the eligibility criteria and were included in our analysis. The frequency of NPKP in Asia, Europe, America, Africa and Oceania was 64.6%, 20.1%, 9.0%, 5.6% and 0.4%, respectively. The most prevalent sequence types (STs) among NPKP were ST11, ST290, ST147, ST340, ST15, ST278 and ST14 based on published studies. CONCLUSION: The dissemination of blaNDM variants in different STs among NPKP in the various region of world is a serious concern to public health. The prevalence of NPKP should be controlled by comprehensive infection control measures and optimization of antibiotic therapy.
Authors: Paweł Kwiatkowski; Monika Sienkiewicz; Agata Pruss; Łukasz Łopusiewicz; Nikola Arszyńska; Iwona Wojciechowska-Koszko; Anna Kilanowicz; Barbara Kot; Barbara Dołęgowska Journal: Antibiotics (Basel) Date: 2022-01-24