| Literature DB >> 33157049 |
James Brugarolas1, Satwik Rajaram2, Alana Christie3, Payal Kapur4.
Abstract
Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene.Entities:
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Year: 2020 PMID： 33157049 DOI： 10.1016/j.ccell.2020.10.021
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 38.585