Claudia Manini1,2, Estíbaliz López-Fernández3,4, Charles H Lawrie5,6,7, Annick Laruelle7,8, Javier C Angulo9,10, José I López11,12. 1. Department of Pathology, San Giovanni Bosco Hospital, 10154, Turin, Italy. 2. Department of Sciences of Public Health and Pediatrics, University of Turin, 10124, Turin, Italy. 3. FISABIO Foundation, 46020, Valencia, Spain. 4. Department of Health Sciences, European University of Valencia, 46023, Valencia, Spain. 5. Molecular Oncology Group, Biodonostia Research Institute, 20014, San Sebastian, Gipuzkoa, Spain. 6. Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK. 7. Basque Foundation for Science, IKERBASQUE, 48011, Bilbao, Bizkaia, Spain. 8. Department of Economic Analysis, University of the Basque Country (UPV/EHU), 48015, Bilbao, Spain. 9. Clinical Department, Faculty of Medical Sciences, European University of Madrid, 28005, Madrid, Spain. 10. Department of Urology, University Hospital of Getafe, 28907, Getafe, Madrid, Spain. 11. Department of Pathology, Cruces University Hospital, Plaza de Cruces S/N, 48903, Barakaldo, Bizkaia, Spain. jilpath@gmail.com. 12. Biomarkers in Cancer Group, Biocruces-Bizkaia Research Institute, 48903, Barakaldo, Spain. jilpath@gmail.com.
Abstract
PURPOSE OF REVIEW: Intratumor heterogeneity (ITH) is an inherent characteristic of most tumors and its detection remains a key task for pathologists. However, the clinical significance of the degree of development of this feature is still poorly understood. RECENT FINDINGS: A series of 28 clear cell renal cell carcinomas (CCRCC) have been exhaustively analyzed with two different sampling protocols [multisite tumor sampling (MSTS) and total sampling] to evaluate to what point the level (low vs. high) of histological ITH detected in routine practice influences tumor behavior and patients' survival. All CCRCC (n = 14) pursuing an aggressive clinical course presented low levels of ITH. A significant worse survival was detected in CCRCC with low ITH (p < 0.001). The simple quantification of the level of ITH using extensive sampling protocol may be of help in predicting tumor evolution, since all CCRCC with aggressive behavior demonstrated low levels of histological ITH.
PURPOSE OF REVIEW: Intratumor heterogeneity (ITH) is an inherent characteristic of most tumors and its detection remains a key task for pathologists. However, the clinical significance of the degree of development of this feature is still poorly understood. RECENT FINDINGS: A series of 28 clear cell renal cell carcinomas (CCRCC) have been exhaustively analyzed with two different sampling protocols [multisite tumor sampling (MSTS) and total sampling] to evaluate to what point the level (low vs. high) of histological ITH detected in routine practice influences tumor behavior and patients' survival. All CCRCC (n = 14) pursuing an aggressive clinical course presented low levels of ITH. A significant worse survival was detected in CCRCC with low ITH (p < 0.001). The simple quantification of the level of ITH using extensive sampling protocol may be of help in predicting tumor evolution, since all CCRCC with aggressive behavior demonstrated low levels of histological ITH.
Authors: Brett Delahunt; John C Cheville; Guido Martignoni; Peter A Humphrey; Cristina Magi-Galluzzi; Jesse McKenney; Lars Egevad; Ferran Algaba; Holger Moch; David J Grignon; Rodolfo Montironi; John R Srigley Journal: Am J Surg Pathol Date: 2013-10 Impact factor: 6.394
Authors: Hemamali Samaratunga; Brett Delahunt; John R Srigley; Daniel M Berney; Liang Cheng; Andrew Evans; Bungo Furusato; Katia R M Leite; Gregory T MacLennan; Guido Martignoni; Holger Moch; Chin-Chen Pan; Gladell Paner; Jae Ro; Michelle Thunders; Toyonori Tsuzuki; Thomas Wheeler; Theodorus van der Kwast; Murali Varma; Sean R Williamson; John W Yaxley; Lars Egevad Journal: Pathology Date: 2020-06-16 Impact factor: 5.306
Authors: Samra Turajlic; Hang Xu; Kevin Litchfield; Andrew Rowan; Tim Chambers; Jose I Lopez; David Nicol; Tim O'Brien; James Larkin; Stuart Horswell; Mark Stares; Lewis Au; Mariam Jamal-Hanjani; Ben Challacombe; Ashish Chandra; Steve Hazell; Claudia Eichler-Jonsson; Aspasia Soultati; Simon Chowdhury; Sarah Rudman; Joanna Lynch; Archana Fernando; Gordon Stamp; Emma Nye; Faiz Jabbar; Lavinia Spain; Sharanpreet Lall; Rosa Guarch; Mary Falzon; Ian Proctor; Lisa Pickering; Martin Gore; Thomas B K Watkins; Sophia Ward; Aengus Stewart; Renzo DiNatale; Maria F Becerra; Ed Reznik; James J Hsieh; Todd A Richmond; George F Mayhew; Samantha M Hill; Catherine D McNally; Carol Jones; Heidi Rosenbaum; Stacey Stanislaw; Daniel L Burgess; Nelson R Alexander; Charles Swanton Journal: Cell Date: 2018-04-12 Impact factor: 41.582
Authors: Samra Turajlic; Hang Xu; Kevin Litchfield; Andrew Rowan; Stuart Horswell; Tim Chambers; Tim O'Brien; Jose I Lopez; Thomas B K Watkins; David Nicol; Mark Stares; Ben Challacombe; Steve Hazell; Ashish Chandra; Thomas J Mitchell; Lewis Au; Claudia Eichler-Jonsson; Faiz Jabbar; Aspasia Soultati; Simon Chowdhury; Sarah Rudman; Joanna Lynch; Archana Fernando; Gordon Stamp; Emma Nye; Aengus Stewart; Wei Xing; Jonathan C Smith; Mickael Escudero; Adam Huffman; Nik Matthews; Greg Elgar; Ben Phillimore; Marta Costa; Sharmin Begum; Sophia Ward; Max Salm; Stefan Boeing; Rosalie Fisher; Lavinia Spain; Carolina Navas; Eva Grönroos; Sebastijan Hobor; Sarkhara Sharma; Ismaeel Aurangzeb; Sharanpreet Lall; Alexander Polson; Mary Varia; Catherine Horsfield; Nicos Fotiadis; Lisa Pickering; Roland F Schwarz; Bruno Silva; Javier Herrero; Nick M Luscombe; Mariam Jamal-Hanjani; Rachel Rosenthal; Nicolai J Birkbak; Gareth A Wilson; Orsolya Pipek; Dezso Ribli; Marcin Krzystanek; Istvan Csabai; Zoltan Szallasi; Martin Gore; Nicholas McGranahan; Peter Van Loo; Peter Campbell; James Larkin; Charles Swanton Journal: Cell Date: 2018-04-12 Impact factor: 41.582
Authors: Thomas J Mitchell; Samra Turajlic; Andrew Rowan; David Nicol; James H R Farmery; Tim O'Brien; Inigo Martincorena; Patrick Tarpey; Nicos Angelopoulos; Lucy R Yates; Adam P Butler; Keiran Raine; Grant D Stewart; Ben Challacombe; Archana Fernando; Jose I Lopez; Steve Hazell; Ashish Chandra; Simon Chowdhury; Sarah Rudman; Aspasia Soultati; Gordon Stamp; Nicos Fotiadis; Lisa Pickering; Lewis Au; Lavinia Spain; Joanna Lynch; Mark Stares; Jon Teague; Francesco Maura; David C Wedge; Stuart Horswell; Tim Chambers; Kevin Litchfield; Hang Xu; Aengus Stewart; Reza Elaidi; Stéphane Oudard; Nicholas McGranahan; Istvan Csabai; Martin Gore; P Andrew Futreal; James Larkin; Andy G Lynch; Zoltan Szallasi; Charles Swanton; Peter J Campbell Journal: Cell Date: 2018-04-12 Impact factor: 41.582