Literature DB >> 33155437

Iron out, mitophagy in! A way to slow down hepatocellular carcinoma.

Yahyah Aman1, Shuqin Cao1,2, Evandro F Fang1,3.   

Abstract

Mitochondrial homeostasis is necessary for the maintenance of cellular function and neuronal survival. Mitochondrial quality is tightly regulated by mitophagy, in which defective/superfluous mitochondria are degraded and recycled. Here, Hara et al demonstrate that induction of mitophagy via iron depletion suppresses the development of hepatocellular carcinoma (HCC). This work suggests turning up mitophagy as a potential therapeutic strategy against liver cancer.
© 2020 The Authors.

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Year:  2020        PMID： 33155437      PMCID： PMC7645234          DOI： 10.15252/embr.202051652

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  10 in total

1.  Deferoxamine for advanced hepatocellular carcinoma.

Authors:  Takahiro Yamasaki; Shuji Terai; Isao Sakaida
Journal:  N Engl J Med       Date:  2011-08-11       Impact factor: 91.245

Review 2.  Mechanisms of mitophagy in cellular homeostasis, physiology and pathology.

Authors:  Konstantinos Palikaras; Eirini Lionaki; Nektarios Tavernarakis
Journal:  Nat Cell Biol       Date:  2018-08-28       Impact factor: 28.824

3.  Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.

Authors:  Natalia V Kirienko; Frederick M Ausubel; Gary Ruvkun
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-26       Impact factor: 11.205

4.  Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans.

Authors:  Alfonso Schiavi; Silvia Maglioni; Konstantinos Palikaras; Anjumara Shaik; Flavie Strappazzon; Vanessa Brinkmann; Alessandro Torgovnick; Natascha Castelein; Sasha De Henau; Bart P Braeckman; Francesco Cecconi; Nektarios Tavernarakis; Natascia Ventura
Journal:  Curr Biol       Date:  2015-07-02       Impact factor: 10.834

Review 5.  Protecting the mitochondrial powerhouse.

Authors:  Morten Scheibye-Knudsen; Evandro F Fang; Deborah L Croteau; David M Wilson; Vilhelm A Bohr
Journal:  Trends Cell Biol       Date:  2014-12-11       Impact factor: 20.808

6.  Iron loss triggers mitophagy through induction of mitochondrial ferritin.

Authors:  Izumi Yanatori; Atsushi Tanaka; Yuichi Hara; Fumio Kishi; John J Lemasters; Sohji Nishina; Kyo Sasaki; Keisuke Hino
Journal:  EMBO Rep       Date:  2020-09-25       Impact factor: 8.807

7.  Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.

Authors:  Evandro F Fang; Yujun Hou; Konstantinos Palikaras; Bryan A Adriaanse; Jesse S Kerr; Beimeng Yang; Sofie Lautrup; Md Mahdi Hasan-Olive; Domenica Caponio; Xiuli Dan; Paula Rocktäschel; Deborah L Croteau; Mansour Akbari; Nigel H Greig; Tormod Fladby; Hilde Nilsen; M Zameel Cader; Mark P Mattson; Nektarios Tavernarakis; Vilhelm A Bohr
Journal:  Nat Neurosci       Date:  2019-02-11       Impact factor: 24.884

8.  The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications.

Authors:  Yahyah Aman; Johannes Frank; Sofie Hindkjær Lautrup; Adrian Matysek; Zhangming Niu; Guang Yang; Liu Shi; Linda H Bergersen; Jon Storm-Mathisen; Lene J Rasmussen; Vilhelm A Bohr; Hilde Nilsen; Evandro F Fang
Journal:  Mech Ageing Dev       Date:  2019-12-05       Impact factor: 5.432

9.  Loss of iron triggers PINK1/Parkin-independent mitophagy.

Authors:  George F G Allen; Rachel Toth; John James; Ian G Ganley
Journal:  EMBO Rep       Date:  2013-11-01       Impact factor: 8.807

10.  Mitophagy and NAD+ inhibit Alzheimer disease.

Authors:  Evandro F Fang
Journal:  Autophagy       Date:  2019-03-28       Impact factor: 16.016
  10 in total

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