OBJECTIVES: Continuous improvement in the management of patients undergoing surgical aortic valve replacement (SAVR) may have considerably enhanced surgical outcomes including in-hospital mortality and perioperative complications. We aimed to analyse in-hospital mortality and morbidity trends in patients undergoing SAVR in a single centre to provide insights for future benchmarking for transcatheter aortic valve implantation indications. METHODS: This was a retrospective study of prospectively collected data from patients undergoing either isolated SAVR or combined with coronary artery bypass grafting (CABG) at the Bristol Heart Institute, UK, from January 2000 to December 2017. Baseline characteristics were extracted and analysed across 3 different eras (2000-2005, 2006-2011 and 2012-2017). Risk-adjusted time trend was obtained from univariate and multivariate logistic regression including all baseline characteristics. RESULTS: A total of 2719 patients (63.2%) underwent isolated SAVR, and 1581 (36.8%) underwent combined CABG and SAVR during the study period. For patients undergoing SAVR, in-hospital mortality decreased from 2.9% in 2000-2005 to 0.7% in 2012-2017 (risk-adjusted time trend 0.0001). Hospital mortality in patients aged 75-79 and ≥80 years decreased from 5.6% and 5.3% to 0.4% and 2.2%, respectively. Mortality after combined SAVR and CABG did not significantly decrease (from 3.9% in 2000-2005 to 3.5% in 2012-2017; risk-adjusted time trend = 0.62). However, in patients aged ≥80 years, index hospitalization mortality showed a decreasing non-significant trend from 9.8% to 4.8%. CONCLUSIONS: Our findings support the hypothesis that mortality and morbidity rates following SAVR have significantly improved over the years, including for patients at high risk.
OBJECTIVES: Continuous improvement in the management of patients undergoing surgical aortic valve replacement (SAVR) may have considerably enhanced surgical outcomes including in-hospital mortality and perioperative complications. We aimed to analyse in-hospital mortality and morbidity trends in patients undergoing SAVR in a single centre to provide insights for future benchmarking for transcatheter aortic valve implantation indications. METHODS: This was a retrospective study of prospectively collected data from patients undergoing either isolated SAVR or combined with coronary artery bypass grafting (CABG) at the Bristol Heart Institute, UK, from January 2000 to December 2017. Baseline characteristics were extracted and analysed across 3 different eras (2000-2005, 2006-2011 and 2012-2017). Risk-adjusted time trend was obtained from univariate and multivariate logistic regression including all baseline characteristics. RESULTS: A total of 2719 patients (63.2%) underwent isolated SAVR, and 1581 (36.8%) underwent combined CABG and SAVR during the study period. For patients undergoing SAVR, in-hospital mortality decreased from 2.9% in 2000-2005 to 0.7% in 2012-2017 (risk-adjusted time trend 0.0001). Hospital mortality in patients aged 75-79 and ≥80 years decreased from 5.6% and 5.3% to 0.4% and 2.2%, respectively. Mortality after combined SAVR and CABG did not significantly decrease (from 3.9% in 2000-2005 to 3.5% in 2012-2017; risk-adjusted time trend = 0.62). However, in patients aged ≥80 years, index hospitalization mortality showed a decreasing non-significant trend from 9.8% to 4.8%. CONCLUSIONS: Our findings support the hypothesis that mortality and morbidity rates following SAVR have significantly improved over the years, including for patients at high risk.
Authors: Luise Gaede; Johannes Blumenstein; Won-Keun Kim; Christoph Liebetrau; Oliver Dörr; Holger Nef; Christian Hamm; Albrecht Elsässer; Helge Möllmann Journal: Clin Res Cardiol Date: 2017-01-11 Impact factor: 5.460
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Authors: R Ascione; M Caputo; W J Gomes; A A Lotto; A J Bryan; G D Angelini; M-S Suleiman Journal: Eur J Cardiothorac Surg Date: 2002-03 Impact factor: 4.191
Authors: Samir R Kapadia; Martin B Leon; Raj R Makkar; E Murat Tuzcu; Lars G Svensson; Susheel Kodali; John G Webb; Michael J Mack; Pamela S Douglas; Vinod H Thourani; Vasilis C Babaliaros; Howard C Herrmann; Wilson Y Szeto; Augusto D Pichard; Mathew R Williams; Gregory P Fontana; D Craig Miller; William N Anderson; Jodi J Akin; Michael J Davidson; Craig R Smith Journal: Lancet Date: 2015-03-15 Impact factor: 79.321
Authors: Shikhar Agarwal; Aatish Garg; Akhil Parashar; Lars G Svensson; E Murat Tuzcu; Jose L Navia; Stephanie Mick; Samir R Kapadia Journal: J Thorac Cardiovasc Surg Date: 2015-06-05 Impact factor: 5.209
Authors: Martine Gilard; Hélène Eltchaninoff; Bernard Iung; Patrick Donzeau-Gouge; Karine Chevreul; Jean Fajadet; Pascal Leprince; Alain Leguerrier; Michel Lievre; Alain Prat; Emmanuel Teiger; Thierry Lefevre; Dominique Himbert; Didier Tchetche; Didier Carrié; Bernard Albat; Alain Cribier; Gilles Rioufol; Arnaud Sudre; Didier Blanchard; Frederic Collet; Pierre Dos Santos; Nicolas Meneveau; Ashok Tirouvanziam; Christophe Caussin; Philippe Guyon; Jacques Boschat; Herve Le Breton; Frederic Collart; Remi Houel; Stephane Delpine; Geraud Souteyrand; Xavier Favereau; Patrick Ohlmann; Vincent Doisy; Gilles Grollier; Antoine Gommeaux; Jean-Philippe Claudel; Francois Bourlon; Bernard Bertrand; Eric Van Belle; Marc Laskar Journal: N Engl J Med Date: 2012-05-03 Impact factor: 91.245
Authors: Hardy Baumbach; Eva R Schairer; Kristina Wachter; Christian Rustenbach; Samir Ahad; Alina Stan; Stephan Hill; Peter Bramlage; Ulrich F W Franke; Tim Schäufele Journal: BMC Cardiovasc Disord Date: 2019-05-14 Impact factor: 2.298