Literature DB >> 3481265

Hepatic carbon flux after re-feeding in the glycogen-storage-disease (gsd/gsd) rat.

M J Holness1, T N Palmer, E B Worrall, M C Sugden.   

Abstract

In this study we utilized the phosphorylase b kinase-deficient (gsd/gsd) rat as a model of hepatic substrate utilization where there is a constraint on glycogenesis imposed by the maintenance of high glycogen concentrations. Glucose re-feeding of 48 h-starved gsd/gsd rats led to suppression of hepatic glucose output. In contrast with the situation in normal rats, activation of the pyruvate dehydrogenase complex and lipogenesis was observed. It is suggested that impeding glycogenic flux may divert substrate into lipogenesis, possibly via activation of the pyruvate dehydrogenase complex.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3481265      PMCID： PMC1148646          DOI： 10.1042/bj2480969

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  31 in total

1.  Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats.

Authors:  D Stansbie; R W Brownsey; M Crettaz; R M Denton
Journal:  Biochem J       Date:  1976-11-15       Impact factor: 3.857

2.  Studies on the alpha-adrenergic activation of hepatic glucose output. I. Studies on the alpha-adrenergic activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase in isolated rat liver parenchymal cells.

Authors:  N J Hutson; F T Brumley; F D Assimacopoulos; S C Harper; J H Exton
Journal:  J Biol Chem       Date:  1976-09-10       Impact factor: 5.157

3.  Lipogenesis in rat hepatocytes.

Authors:  D G Clark; R Rognstad; J Katz
Journal:  J Biol Chem       Date:  1974-04-10       Impact factor: 5.157

4.  Fatty acid and 3- -hydroxysterol synthesis in the perfused rat liver. Including measurements on the production of lactate, pyruvate, -hydroxy-butyrate, and acetoacetate by the fed liver.

Authors:  H Brunengraber; M Boutry; J M Lowenstein
Journal:  J Biol Chem       Date:  1973-04-25       Impact factor: 5.157

5.  Fatty acid synthesis in liver and adipose tissue of normal and genetically obese (ob/ob) mice during the 24-hour cycle.

Authors:  D A Hems; E A Rath; T R Verrinder
Journal:  Biochem J       Date:  1975-08       Impact factor: 3.857

6.  Comparative effects of (--)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo.

Authors:  J Triscari; A C Sullivan
Journal:  Lipids       Date:  1977-04       Impact factor: 1.880

7.  Glucose load diverts hepatic gluconeogenic product from glucose to glycogen in vivo.

Authors:  H Shikama; M Ui
Journal:  Am J Physiol       Date:  1978-10

8.  Fatty acid, 3-beta-hydroxysterol, and ketone synthesis in the perfused rat liver. Effects of (--)-hydroxycitrate and oleate.

Authors:  H Brunengraber; M Boutry; J M Lowenstein
Journal:  Eur J Biochem       Date:  1978-01-16

9.  Synthesis of fatty acids in the perused mouse liver.

Authors:  D M Salmon; N L Bowen; D A Hems
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

10.  The relationship between fat synthesis and oxidation in the liver after re-feeding and its regulation by thyroid hormone.

Authors:  M J Holness; T J French; P S Schofield; M C Sugden
Journal:  Biochem J       Date:  1987-11-01       Impact factor: 3.857
View more
  5 in total

Review 1.  Fuel selection and carbon flux during the starved-to-fed transition.

Authors:  M C Sugden; M J Holness; T N Palmer
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

2.  Suppression of hepatic glucose output after glucose re-feeding in the gsd/gsd rat.

Authors:  M J Holness; T N Palmer; M C Sugden
Journal:  Biochem J       Date:  1988-06-15       Impact factor: 3.857

3.  Regulation of hepatic fructose 2,6-bisphosphate concentrations and lipogenesis after re-feeding in euthyroid and hyperthyroid rats. A regulatory role for glycogenesis.

Authors:  M J Holness; E B Cook; M C Sugden
Journal:  Biochem J       Date:  1988-06-01       Impact factor: 3.857

4.  A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism.

Authors:  Nikolaus Berndt; Marius Stefan Horger; Sascha Bulik; Hermann-Georg Holzhütter
Journal:  PLoS Comput Biol       Date:  2018-02-15       Impact factor: 4.475

5.  The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism--insights from mathematical modeling.

Authors:  Sascha Bulik; Hermann-Georg Holzhütter; Nikolaus Berndt
Journal:  BMC Biol       Date:  2016-03-02       Impact factor: 7.431
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.