Shinya Kamimura1, Akinori Tamura1, Tomotaka Ishii1, Tatsuo Kanda2, Mitsuhiko Moriyama1. 1. Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan. 2. Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan kanda.tatsuo@nihon-u.ac.jp.
Abstract
BACKGROUND/AIM: Hepatitis C virus (HCV) infection is an important health problem in the direct-acting antivirals-era. HCV causes life-threatening diseases, such as cirrhosis and hepatocellular carcinoma. Our aim was to examine whether certain single-nucleotide polymorphisms (SNPs) are associated with the prevalence of HCV infections progressing to cirrhosis in the Japanese population by a genome-wide association study-based approach. MATERIALS AND METHODS: We used DNA extracted from blood specimens of Japanese subjects with the establishment of the BioBank Japan project. RESULTS: We observed statistically significant differences in the frequency of 4 SNPs (rs1989972, rs2293766, rs1877033 and rs4805439) between anti-HCV-positive cirrhotic patients and controls. CONCLUSION: Four SNPs are associated with susceptibility to cirrhosis among HCV-infected Japanese subjects, while further studies with cohorts other than those sourced from BioBank Japan, must be conducted. Copyright
BACKGROUND/AIM: Hepatitis C virus (HCV) infection is an important health problem in the direct-acting antivirals-era. HCV causes life-threatening diseases, such as cirrhosis and hepatocellular carcinoma. Our aim was to examine whether certain single-nucleotide polymorphisms (SNPs) are associated with the prevalence of HCV infections progressing to cirrhosis in the Japanese population by a genome-wide association study-based approach. MATERIALS AND METHODS: We used DNA extracted from blood specimens of Japanese subjects with the establishment of the BioBank Japan project. RESULTS: We observed statistically significant differences in the frequency of 4 SNPs (rs1989972, rs2293766, rs1877033 and rs4805439) between anti-HCV-positive cirrhotic patients and controls. CONCLUSION: Four SNPs are associated with susceptibility to cirrhosis among HCV-infected Japanese subjects, while further studies with cohorts other than those sourced from BioBank Japan, must be conducted. Copyright
Authors: Pradip B Devhare; Reina Sasaki; Shubham Shrivastava; Adrian M Di Bisceglie; Ranjit Ray; Ratna B Ray Journal: J Virol Date: 2017-02-28 Impact factor: 5.103
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