Soon Sun Kim1, Jung Woo Eun1, Hyo Jung Cho1, Hyun-Young Lee2, Chul Won Seo3, Choong Kyun Noh1, Sung Jae Shin1, Kee Myung Lee1, Sung Won Cho1, Jae Youn Cheong4. 1. Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea. 2. Clinical Trial Center, Ajou University Hospital, Suwon, Republic of Korea. 3. Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Republic of Korea. 4. Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea jaeyoun620@gmail.com.
Abstract
BACKGROUND/AIM: Fibroblast growth factor (FGF), vascular endothelial growth factor, and hepatocyte growth factor play a critical role in the pathogenesis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: We assessed nine single nucleotide polymorphisms (SNPs) in the FGF1, FGF2, FGF receptor (FGFR)-2, Flt-1, and c-MET genes in 245 HCC patients and 483 chronic hepatitis B virus (HBV) carriers without HCC. RESULTS: Kaplan-Meier analysis showed that patients with the FGF2 rs308447 TT genotype had shorter overall survival than patients with the CC or CT genotype (p=0.016) and that FGF2 rs308379 A allele carriers had shorter overall survival than patients with the TT genotype (p=0.020). CONCLUSION: Multivariate Cox proportional analysis revealed that the FGF2 rs308379 A allele (hazard ratio(HR)=1.663, p=0.004) and advanced tumor stage (HR=3.430, p<0.001) were independent prognostic factors for overall survival in patients with HCC. Copyright
BACKGROUND/AIM: Fibroblast growth factor (FGF), vascular endothelial growth factor, and hepatocyte growth factor play a critical role in the pathogenesis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: We assessed nine single nucleotide polymorphisms (SNPs) in the FGF1, FGF2, FGF receptor (FGFR)-2, Flt-1, and c-MET genes in 245 HCC patients and 483 chronic hepatitis B virus (HBV) carriers without HCC. RESULTS: Kaplan-Meier analysis showed that patients with the FGF2rs308447 TT genotype had shorter overall survival than patients with the CC or CT genotype (p=0.016) and that FGF2rs308379 A allele carriers had shorter overall survival than patients with the TT genotype (p=0.020). CONCLUSION: Multivariate Cox proportional analysis revealed that the FGF2rs308379 A allele (hazard ratio(HR)=1.663, p=0.004) and advanced tumor stage (HR=3.430, p<0.001) were independent prognostic factors for overall survival in patients with HCC. Copyright
Authors: Kemper Nunes Dos Santos; Rodrigo M Florentino; Andressa França; Antônio Carlos Melo Lima Filho; Marcone Loiola Dos Santos; Dabny Missiaggia; Matheus de Castro Fonseca; Igor Brasil Costa; Paula Vieira Teixeira Vidigal; Michael H Nathanson; Fernanda de Oliveira Lemos; M Fatima Leite Journal: Int J Mol Sci Date: 2019-07-23 Impact factor: 5.923