Paulina Borecka1, Rafal Ciaputa2, Izabela Janus2, Joanna Bubak2, Aleksandra Piotrowska3, Katarzyna Ratajczak-Wielgomas3, Marzenna Podhorska-OkolÓw4, Piotr DziĘgiel3,5, Marcin Nowak2. 1. Department of Pathology, Division of Pathomorphology and Forensic Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland paulina.borecka@upwr.edu.pl. 2. Department of Pathology, Division of Pathomorphology and Forensic Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland. 3. Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland. 4. Division of Ultrastructure Research, Wroclaw Medical University, Wroclaw, Poland. 5. Department of Physiotherapy, University School of Physical Education in Wroclaw, Wroclaw, Poland.
Abstract
BACKGROUND/AIM: Periostin (POSTN) has a significant role in proliferation and migration of tumour cells as well as tumour progression. This study aimed to determinate POSTN expression in cancer cells in malignant and benign tumours of the mammary gland in female dogs. MATERIALS AND METHODS: All together 83 cancers, 24 adenomas and 7 unchanged fragments of the mammary glands of bitches were investigated. Immunohistochemistry was performed using anti-POSTN, Ki-67 and HER2 antibodies. RESULTS: POSTN expression was observed in cancer cells in 31.3% of malignancies and 12.5% of benign tumours. A significantly positive correlation between expression of POSTN in cancer cells and the degree of histological malignancy, expression of Ki-67 antigen and expression of POSTN in CAFs was found. CONCLUSION: The obtained results suggest the possible participation of POSTN in the process of carcinogenesis and progression of mammary tumors in bitches. Copyright
BACKGROUND/AIM: Periostin (POSTN) has a significant role in proliferation and migration of tumour cells as well as tumour progression. This study aimed to determinate POSTN expression in cancer cells in malignant and benign tumours of the mammary gland in female dogs. MATERIALS AND METHODS: All together 83 cancers, 24 adenomas and 7 unchanged fragments of the mammary glands of bitches were investigated. Immunohistochemistry was performed using anti-POSTN, Ki-67 and HER2 antibodies. RESULTS:POSTN expression was observed in cancer cells in 31.3% of malignancies and 12.5% of benign tumours. A significantly positive correlation between expression of POSTN in cancer cells and the degree of histological malignancy, expression of Ki-67 antigen and expression of POSTN in CAFs was found. CONCLUSION: The obtained results suggest the possible participation of POSTN in the process of carcinogenesis and progression of mammary tumors in bitches. Copyright
Authors: Paulina Borecka; Katarzyna Ratajczak-Wielgomas; Rafal Ciaputa; Małgorzata Kandefer-Gola; Izabela Janus; Aleksandra Piotrowska; Alicja Kmiecik; Marzena Podhorska-Okolów; Piotr Dzięgiel; Marcin Nowak Journal: In Vivo Date: 2020 May-Jun Impact factor: 2.155
Authors: Antonio C Wolff; M Elizabeth H Hammond; David G Hicks; Mitch Dowsett; Lisa M McShane; Kimberly H Allison; Donald C Allred; John M S Bartlett; Michael Bilous; Patrick Fitzgibbons; Wedad Hanna; Robert B Jenkins; Pamela B Mangu; Soonmyung Paik; Edith A Perez; Michael F Press; Patricia A Spears; Gail H Vance; Giuseppe Viale; Daniel F Hayes Journal: J Clin Oncol Date: 2013-10-07 Impact factor: 44.544
Authors: Andreia A Santos; Célia C Lopes; Jorge R Ribeiro; Liliana R Martins; Joana C Santos; Irina F Amorim; Fátima Gärtner; Augusto J Matos Journal: BMC Vet Res Date: 2013-01-04 Impact factor: 2.741