Shoukui Xiang1, Yang Wu1, Huan Shi1, Lian Xue2, Kaiming Luo1, Yi Ding3. 1. Department of Endocrinology, Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou City 213003, China. 2. Modern Medical Research Center, Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou City 213003, China. 3. Department of Geriatrics, Third Affiliated Hospital of Soochow University, Jiangsu, Changzhou City 213003, China.
Abstract
Background: The present study evaluated the potential of hsa_circ_0001445 as a biomarker in plasma for postmenopausal patients with osteoporosis (OPO). Materials & methods: The expression levels of hsa_circ_0001445 in plasma were detected in healthy controls, patients with osteopenia (OPE) and patients with OPO by using quantitative reverse-transcriptase PCR. Results: The expression levels of hsa_circ_0001445 in plasma were much lower in OPO patients compared with OPE patients and healthy controls. Its expression was positively correlated with the T-score and was negatively correlated with β-isomerized C-terminal telopeptides (β-CTx). It could distinguish OPE or/and OPO patients from healthy controls. Moreover, its expression was significantly upregulated in the plasma of OPO patients after anti-osteoporotic treatment. Conclusion: Hsa_circ_0001445 in plasma may be a novel potential diagnostic biomarker for OPO.
Background: The present study evaluated the potential of hsa_circ_0001445 as a biomarker in plasma for postmenopausal patients with osteoporosis (OPO). Materials & methods: The expression levels of hsa_circ_0001445 in plasma were detected in healthy controls, patients with osteopenia (OPE) and patients with OPO by using quantitative reverse-transcriptase PCR. Results: The expression levels of hsa_circ_0001445 in plasma were much lower in OPO patients compared with OPE patients and healthy controls. Its expression was positively correlated with the T-score and was negatively correlated with β-isomerized C-terminal telopeptides (β-CTx). It could distinguish OPE or/and OPO patients from healthy controls. Moreover, its expression was significantly upregulated in the plasma of OPO patients after anti-osteoporotic treatment. Conclusion: Hsa_circ_0001445 in plasma may be a novel potential diagnostic biomarker for OPO.