| Literature DB >> 33137727 |
Sungwoong Jeon1,2, Sangwon Kim3, Shinwon Ha4, Seungmin Lee1,2, Eunhee Kim1,2, So Yeun Kim4, Sun Hwa Park5, Jung Ho Jeon5, Sung Won Kim5,6, Cheil Moon4, Bradley J Nelson1,2,3, Jin-Young Kim7,2, Seong-Woon Yu8, Hongsoo Choi7,2.
Abstract
Magnetic microrobots were developed for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the microrobots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons. Moreover, microrobots were used to transport colorectal carcinoma cancer cells to tumor microtissue in a body-on-a-chip, which comprised an in vitro liver-tumor microorgan network. The microrobots were also controlled in a mouse brain slice and rat brain blood vessel. Last, microrobots carrying mesenchymal stem cells derived from human nose were manipulated inside the intraperitoneal cavity of a nude mouse. The results indicate the potential of microrobots for the culture and delivery of stem cells.Entities:
Year: 2019 PMID： 33137727 DOI： 10.1126/scirobotics.aav4317
Source DB: PubMed Journal: Sci Robot ISSN： 2470-9476