Christie Y Jeon1, Robert Feldman2, Felicity J Pendergast3, Samer AlKaade4, Randall E Brand5, Nalini Guda6, Bimaljit S Sandhu7, Vikesh K Singh8, C Mel Wilcox9, Adam Slivka5, David C Whitcomb5, Dhiraj Yadav5. 1. Cedars Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA. Electronic address: christie.jeon@cshs.org. 2. Center for Research on Healthcare Data Center, University of Pittsburgh, Pittsburgh, PA, USA. 3. Cedars Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 4. Mercy Clinic Gastroenterology, St. Louis, MO, USA. 5. Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 6. Aurora St. Luke's Medical Center, Milwaukee, WI, USA. 7. Gastroenterology Associates, Richmond, VA, USA. 8. Pancreatitis Center, Division of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. 9. Division of Gastroenterology and Hepatology, University of Alabama Birmingham, AL, USA.
Abstract
BACKGROUND/ OBJECTIVES: Black Americans are at increased risk of chronic pancreatitis (CP) compared to their White counterparts. We aimed to describe the race-specific smoking history and lifetime drinking in patients diagnosed with CP. METHODS: We analyzed data on 334 Black and White CP participants of the North American Pancreatitis Study 2 Continuation and Validation Study and Ancillary Study. Lifetime drinking history and lifetime smoking history were collected through in-person interviews. Intensity, frequency, duration and current status of drinking and smoking were compared between Black and White CP participants, stratified by physician-defined alcohol etiology. In addition, drinking levels at each successive decades in life (20s, 30s, 40s) were compared by race and graphically portrayed as heat diagrams. RESULTS: Among patients with alcoholic CP, current smoking levels were not different by race (67-70%), but a smaller proportion of Black patients reported having smoked 1 or more packs per day in the past (32%) as compared to White patients (58%, p < 0.0001). Black patients were more likely to report current consumption of alcohol (31%), as opposed to White patients (17%, p = 0.016). Black patients also reported more intense drinking at age 35 and 45 years as compared to White patients, while age at CP onset were similar between the two groups. CONCLUSION: We found more intense drinking but less intense smoking history in Black CP patients as compared to White CP patients. Effective alcohol abstinence and smoking cessation program with sustained impact are needed in CP patients.
BACKGROUND/ OBJECTIVES: Black Americans are at increased risk of chronic pancreatitis (CP) compared to their White counterparts. We aimed to describe the race-specific smoking history and lifetime drinking in patients diagnosed with CP. METHODS: We analyzed data on 334 Black and White CPparticipants of the North American Pancreatitis Study 2 Continuation and Validation Study and Ancillary Study. Lifetime drinking history and lifetime smoking history were collected through in-person interviews. Intensity, frequency, duration and current status of drinking and smoking were compared between Black and White CPparticipants, stratified by physician-defined alcohol etiology. In addition, drinking levels at each successive decades in life (20s, 30s, 40s) were compared by race and graphically portrayed as heat diagrams. RESULTS: Among patients with alcoholic CP, current smoking levels were not different by race (67-70%), but a smaller proportion of Black patients reported having smoked 1 or more packs per day in the past (32%) as compared to White patients (58%, p < 0.0001). Black patients were more likely to report current consumption of alcohol (31%), as opposed to White patients (17%, p = 0.016). Black patients also reported more intense drinking at age 35 and 45 years as compared to White patients, while age at CP onset were similar between the two groups. CONCLUSION: We found more intense drinking but less intense smoking history in Black CPpatients as compared to White CPpatients. Effective alcohol abstinence and smoking cessation program with sustained impact are needed in CPpatients.
Authors: Christie Y Jeon; David C Whitcomb; Adam Slivka; Randall E Brand; Andres Gelrud; Gong Tang; Judah Abberbock; Samer AlKaade; Nalini Guda; C Mel Wilcox; Bimaljit S Sandhu; Dhiraj Yadav Journal: Alcohol Alcohol Date: 2019-12-01 Impact factor: 2.826
Authors: Veronica Wendy Setiawan; Stephen J Pandol; Jacqueline Porcel; Lynne R Wilkens; Loïc Le Marchand; Malcolm C Pike; Kristine R Monroe Journal: Pancreas Date: 2016-07 Impact factor: 3.327
Authors: C Mel Wilcox; Dhiraj Yadav; Tian Ye; Timothy B Gardner; Andres Gelrud; Bimaljit S Sandhu; Michele D Lewis; Samer Al-Kaade; Gregory A Cote; Christopher E Forsmark; Nalini M Guda; Darwin L Conwell; Peter A Banks; Thiruvengadam Muniraj; Joseph Romagnuolo; Randall E Brand; Adam Slivka; Stuart Sherman; Stephen R Wisniewski; David C Whitcomb; Michelle A Anderson Journal: Clin Gastroenterol Hepatol Date: 2014-10-24 Impact factor: 11.382
Authors: C Mel Wilcox; Bimaljit S Sandhu; Vikesh Singh; Andres Gelrud; Judah N Abberbock; Stuart Sherman; Gregory A Cote; Samer Al-Kaade; Michelle A Anderson; Timothy B Gardner; Michele D Lewis; Christopher E Forsmark; Nalini M Guda; Joseph Romagnuolo; John Baillie; Stephen T Amann; Thiruvengadam Muniraj; Gong Tang; Darwin L Conwell; Peter A Banks; Randall E Brand; Adam Slivka; David Whitcomb; Dhiraj Yadav Journal: Am J Gastroenterol Date: 2016-08-16 Impact factor: 10.864
Authors: Anna Evans Phillips; Jessica LaRusch; Phil Greer; Judah Abberbock; Samer Alkaade; Stephen T Amann; Michelle A Anderson; John Baillie; Peter A Banks; Randall E Brand; Darwin Conwell; Gregory A Coté; Christopher E Forsmark; Timothy B Gardner; Andres Gelrud; Nalini Guda; Michele Lewis; Mary E Money; Thiruvengadam Muniraj; Bimaljit S Sandhu; Stuart Sherman; Vikesh K Singh; Adam Slivka; Gong Tang; C Mel Wilcox; David C Whitcomb; Dhiraj Yadav Journal: Pancreatology Date: 2018-05-19 Impact factor: 3.996
Authors: David C Whitcomb; Jessica LaRusch; Alyssa M Krasinskas; Lambertus Klei; Jill P Smith; Randall E Brand; John P Neoptolemos; Markus M Lerch; Matt Tector; Bimaljit S Sandhu; Nalini M Guda; Lidiya Orlichenko; Samer Alkaade; Stephen T Amann; Michelle A Anderson; John Baillie; Peter A Banks; Darwin Conwell; Gregory A Coté; Peter B Cotton; James DiSario; Lindsay A Farrer; Chris E Forsmark; Marianne Johnstone; Timothy B Gardner; Andres Gelrud; William Greenhalf; Jonathan L Haines; Douglas J Hartman; Robert A Hawes; Christopher Lawrence; Michele Lewis; Julia Mayerle; Richard Mayeux; Nadine M Melhem; Mary E Money; Thiruvengadam Muniraj; Georgios I Papachristou; Margaret A Pericak-Vance; Joseph Romagnuolo; Gerard D Schellenberg; Stuart Sherman; Peter Simon; Vijay P Singh; Adam Slivka; Donna Stolz; Robert Sutton; Frank Ulrich Weiss; C Mel Wilcox; Narcis Octavian Zarnescu; Stephen R Wisniewski; Michael R O'Connell; Michelle L Kienholz; Kathryn Roeder; M Michael Barmada; Dhiraj Yadav; Bernie Devlin Journal: Nat Genet Date: 2012-11-11 Impact factor: 38.330