Christie Y Jeon1,2, David C Whitcomb3, Adam Slivka3, Randall E Brand3, Andres Gelrud3, Gong Tang4, Judah Abberbock4, Samer AlKaade5, Nalini Guda6, C Mel Wilcox7, Bimaljit S Sandhu8, Dhiraj Yadav3. 1. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 2. UCLA Fielding School of Public Health, Los Angeles, CA, USA. 3. Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 4. Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 5. SLUCare Center for Pancreatic Biliary Disorders, Saint Louis University, St. Louis, MO, USA. 6. Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Milwaukee, WI, USA. 7. Division of Gastroenterology and Hepatology, The University of Alabama at Birmingham, Birmingham, AL, USA. 8. Richmond Gastroenterology Associates, Richmond, VA, USA.
Abstract
AIMS: Cumulative consumption of alcohol and variations of alcohol intake by age are unknown in chronic pancreatitis (CP) patients in North America. This study summarizes the lifetime drinking history (LDH) by physician attribution of alcohol etiology, smoking status and sex in persons with CP. METHODS: We analyzed data on 193 CP participants who completed the LDH questionnaire in the North American Pancreatitis Continuation and Validation Study (NAPS2-CV). We collected data on frequency of drinking and drinks per drinking day for each drinking phase of their lives. We examined differences in total number of alcoholic drinks and weight of ethanol consumed by physician's assessment of CP etiology, sex and smoking status. We also compared intensity of drinking in 20, 30 and 40s by timing of CP diagnosis. RESULTS: Persons diagnosed with alcoholic CP consumed median of 34,488 drinks (interquartile range 18,240-75,024) prior to diagnosis of CP, which occurred earlier than in persons with CP of other etiology (47 vs. 52 years). Cumulative drinking was greater in male vs. female patients. Male CP patients with a diagnosis of CP before the age of 45 drank more intensely in their 20s as compared to those with later onset of disease. Current smoking was prevalent (67%) among those diagnosed with alcoholic CP. Twenty-eight percent of patients without physician attribution of alcohol etiology reported drinking heavily in the past. CONCLUSIONS: Lifetime cumulative consumption of alcohol and prevalence of current smoking are high in persons diagnosed with alcoholic pancreatitis. Intense drinking in early years is associated with earlier manifestation of the disease.
AIMS: Cumulative consumption of alcohol and variations of alcohol intake by age are unknown in chronic pancreatitis (CP) patients in North America. This study summarizes the lifetime drinking history (LDH) by physician attribution of alcohol etiology, smoking status and sex in persons with CP. METHODS: We analyzed data on 193 CP participants who completed the LDH questionnaire in the North American Pancreatitis Continuation and Validation Study (NAPS2-CV). We collected data on frequency of drinking and drinks per drinking day for each drinking phase of their lives. We examined differences in total number of alcoholic drinks and weight of ethanol consumed by physician's assessment of CP etiology, sex and smoking status. We also compared intensity of drinking in 20, 30 and 40s by timing of CP diagnosis. RESULTS:Persons diagnosed with alcoholic CP consumed median of 34,488 drinks (interquartile range 18,240-75,024) prior to diagnosis of CP, which occurred earlier than in persons with CP of other etiology (47 vs. 52 years). Cumulative drinking was greater in male vs. female patients. Male CP patients with a diagnosis of CP before the age of 45 drank more intensely in their 20s as compared to those with later onset of disease. Current smoking was prevalent (67%) among those diagnosed with alcoholic CP. Twenty-eight percent of patients without physician attribution of alcohol etiology reported drinking heavily in the past. CONCLUSIONS: Lifetime cumulative consumption of alcohol and prevalence of current smoking are high in persons diagnosed with alcoholic pancreatitis. Intense drinking in early years is associated with earlier manifestation of the disease.
Authors: Dhiraj Yadav; Robert H Hawes; Randall E Brand; Michelle A Anderson; Mary E Money; Peter A Banks; Michele D Bishop; John Baillie; Stuart Sherman; James DiSario; Frank R Burton; Timothy B Gardner; Stephen T Amann; Andres Gelrud; Christopher Lawrence; Beth Elinoff; Julia B Greer; Michael O'Connell; M Michael Barmada; Adam Slivka; David C Whitcomb Journal: Arch Intern Med Date: 2009-06-08
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Authors: L Frulloni; A Gabbrielli; R Pezzilli; A Zerbi; G M Cavestro; F Marotta; M Falconi; E Gaia; G Uomo; A Maringhini; M Mutignani; P Maisonneuve; V Di Carlo; G Cavallini Journal: Dig Liver Dis Date: 2008-12-20 Impact factor: 4.088
Authors: Anna Evans Phillips; Jessica LaRusch; Phil Greer; Judah Abberbock; Samer Alkaade; Stephen T Amann; Michelle A Anderson; John Baillie; Peter A Banks; Randall E Brand; Darwin Conwell; Gregory A Coté; Christopher E Forsmark; Timothy B Gardner; Andres Gelrud; Nalini Guda; Michele Lewis; Mary E Money; Thiruvengadam Muniraj; Bimaljit S Sandhu; Stuart Sherman; Vikesh K Singh; Adam Slivka; Gong Tang; C Mel Wilcox; David C Whitcomb; Dhiraj Yadav Journal: Pancreatology Date: 2018-05-19 Impact factor: 3.996
Authors: Christie Y Jeon; Robert Feldman; Felicity J Pendergast; Samer AlKaade; Randall E Brand; Nalini Guda; Bimaljit S Sandhu; Vikesh K Singh; C Mel Wilcox; Adam Slivka; David C Whitcomb; Dhiraj Yadav Journal: Pancreatology Date: 2020-10-12 Impact factor: 3.996
Authors: Ellyn Dunbar; Phil J Greer; Nadine Melhem; Samer Alkaade; Stephen T Amann; Randall Brand; Gregory A Coté; Christopher E Forsmark; Timothy B Gardner; Andres Gelrud; Nalini M Guda; Jessica LaRusch; Michele D Lewis; Jorge D Machicado; Thiruvengadam Muniraj; Georgios I Papachristou; Joseph Romagnuolo; Bimaljit S Sandhu; Stuart Sherman; Charles M Wilcox; Vikesh K Singh; Dhiraj Yadav; David C Whitcomb Journal: J Gastroenterol Date: 2020-07-17 Impact factor: 6.772