| Literature DB >> 33131572 |
William R Miller1, Barbara E Murray2, Louis B Rice3, Cesar A Arias4.
Abstract
Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.Entities:
Keywords: Colonization resistance; Mechanisms of resistance; VRE; VRE colonization; Vancomycin resistant enterococcus
Mesh:
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Year: 2020 PMID: 33131572 PMCID: PMC7640809 DOI: 10.1016/j.idc.2020.08.004
Source DB: PubMed Journal: Infect Dis Clin North Am ISSN: 0891-5520 Impact factor: 5.982