Literature DB >> 33128782

Tumor start-up: mitochondrial fusion makes it happen.

Ana R Rebelo1, Marcia Garcez1, Catarina Cf Homem1.   

Abstract

Whether changes in cellular metabolism precede tumor formation and trigger malignant properties or simply serve as a bioenergetic adaptation of cancer during disease progression remains debated. Bonnay et al (2020) now show that a metabolic reprogramming toward increased oxidative phosphorylation is required for irreversible cell immortalization and subsequent tumor formation.
© 2020 The Authors.

Entities:  

Mesh：

Year:  2020        PMID： 33128782      PMCID： PMC7705446          DOI： 10.15252/embj.2020106927

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  11 in total

1.  A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.

Authors:  Björn von Eyss; Laura A Jaenicke; Roderik M Kortlever; Nadine Royla; Katrin E Wiese; Sebastian Letschert; Leigh-Anne McDuffus; Markus Sauer; Andreas Rosenwald; Gerard I Evan; Stefan Kempa; Martin Eilers
Journal:  Cancer Cell       Date:  2015-12-14       Impact factor: 31.743

2.  Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells.

Authors:  Catarina C F Homem; Victoria Steinmann; Thomas R Burkard; Alexander Jais; Harald Esterbauer; Juergen A Knoblich
Journal:  Cell       Date:  2014-08-14       Impact factor: 41.582

3.  Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors.

Authors:  Raphaël Clément; Cassandra Gaultier; Sara Genovese; Florence Besse; Karine Narbonne-Reveau; Fabrice Daian; Sophie Foppolo; Nuno Miguel Luis; Cédric Maurange
Journal:  Elife       Date:  2019-09-30       Impact factor: 8.140

4.  Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

Authors:  Joerg Betschinger; Karl Mechtler; Juergen A Knoblich
Journal:  Cell       Date:  2006-03-24       Impact factor: 41.582

5.  Metabolic Heterogeneity in Human Lung Tumors.

Authors:  Christopher T Hensley; Brandon Faubert; Qing Yuan; Naama Lev-Cohain; Eunsook Jin; Jiyeon Kim; Lei Jiang; Bookyung Ko; Rachael Skelton; Laurin Loudat; Michelle Wodzak; Claire Klimko; Elizabeth McMillan; Yasmeen Butt; Min Ni; Dwight Oliver; Jose Torrealba; Craig R Malloy; Kemp Kernstine; Robert E Lenkinski; Ralph J DeBerardinis
Journal:  Cell       Date:  2016-02-04       Impact factor: 41.582

6.  Tumor start-up: mitochondrial fusion makes it happen.

Authors:  Ana R Rebelo; Marcia Garcez; Catarina Cf Homem
Journal:  EMBO J       Date:  2020-10-31       Impact factor: 11.598

7.  The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila.

Authors:  Sarah K Bowman; Vivien Rolland; Joerg Betschinger; Kaolin A Kinsey; Gregory Emery; Juergen A Knoblich
Journal:  Dev Cell       Date:  2008-03-13       Impact factor: 12.270

8.  Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis.

Authors:  François Bonnay; Ana Veloso; Victoria Steinmann; Thomas Köcher; Merve Deniz Abdusselamoglu; Sunanjay Bajaj; Elisa Rivelles; Lisa Landskron; Harald Esterbauer; Robert P Zinzen; Juergen A Knoblich
Journal:  Cell       Date:  2020-09-10       Impact factor: 41.582

Review 9.  Oxidative Phosphorylation as an Emerging Target in Cancer Therapy.

Authors:  Leoni A Kunz-Schughart; Geoff S Higgins; Thomas M Ashton; W Gillies McKenna
Journal:  Clin Cancer Res       Date:  2018-02-02       Impact factor: 12.531

10.  Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth.

Authors:  Meng Li; Ling Wang; Yijin Wang; Shaoshi Zhang; Guoying Zhou; Ruby Lieshout; Buyun Ma; Jiaye Liu; Changbo Qu; Monique M A Verstegen; Dave Sprengers; Jaap Kwekkeboom; Luc J W van der Laan; Wanlu Cao; Maikel P Peppelenbosch; Qiuwei Pan
Journal:  Cells       Date:  2020-01-04       Impact factor: 6.600
View more
  2 in total

1.  Tumor start-up: mitochondrial fusion makes it happen.

Authors:  Ana R Rebelo; Marcia Garcez; Catarina Cf Homem
Journal:  EMBO J       Date:  2020-10-31       Impact factor: 11.598

Review 2.  Mitochondrial quality control in diabetic cardiomyopathy: from molecular mechanisms to therapeutic strategies.

Authors:  Chen Cai; Feng Wu; Jing He; Yaoyuan Zhang; Nengxian Shi; Xiaojie Peng; Qing Ou; Ziying Li; Xiaoqing Jiang; Jiankai Zhong; Ying Tan
Journal:  Int J Biol Sci       Date:  2022-08-15       Impact factor: 10.750
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.