Literature DB >> 33122444

Opinion: For now, it's unethical to use human challenge studies for SARS-CoV-2 vaccine development.

Jeffrey P Kahn1, Leslie Meltzer Henry2,3, Anna C Mastroianni4,5, Wilbur H Chen6, Ruth Macklin7.   

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Year:  2020        PMID： 33122444      PMCID： PMC7682548          DOI： 10.1073/pnas.2021189117

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  18 in total

1.  The ethical challenge of infection-inducing challenge experiments.

Authors:  F G Miller; C Grady
Journal:  Clin Infect Dis       Date:  2001-09-05       Impact factor: 9.079

2.  Dozens to be deliberately infected with coronavirus in UK 'human challenge' trials.

Authors:  Ewen Callaway
Journal:  Nature       Date:  2020-10       Impact factor: 49.962

3.  Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection.

Authors:  Saurabh Rajpal; Matthew S Tong; James Borchers; Karolina M Zareba; Timothy P Obarski; Orlando P Simonetti; Curt J Daniels
Journal:  JAMA Cardiol       Date:  2021-01-01       Impact factor: 14.676

4.  Against pandemic research exceptionalism.

Authors:  Alex John London; Jonathan Kimmelman
Journal:  Science       Date:  2020-04-23       Impact factor: 47.728

5.  COVID-19 and Racial/Ethnic Disparities.

Authors:  Monica Webb Hooper; Anna María Nápoles; Eliseo J Pérez-Stable
Journal:  JAMA       Date:  2020-06-23       Impact factor: 157.335

Review 6.  So much at stake: Ethical tradeoffs in accelerating SARSCoV-2 vaccine development.

Authors:  Christine Grady; Seema Shah; Franklin Miller; Marion Danis; Marie Nicolini; Jorge Ochoa; Holly Taylor; Dave Wendler; Annette Rid
Journal:  Vaccine       Date:  2020-08-11       Impact factor: 3.641

Review 7.  COVID-19 human challenge studies: ethical issues.

Authors:  Euzebiusz Jamrozik; Michael J Selgelid
Journal:  Lancet Infect Dis       Date:  2020-05-29       Impact factor: 25.071

8.  Controlled human infection with SARS-CoV-2 to study COVID-19 vaccines and treatments: bioethics in Utopia.

Authors:  Søren Holm
Journal:  J Med Ethics       Date:  2020-07-02       Impact factor: 2.903

9.  Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure.

Authors:  Nir Eyal; Marc Lipsitch; Peter G Smith
Journal:  J Infect Dis       Date:  2020-05-11       Impact factor: 5.226

10.  Why Challenge Trials of SARS-CoV-2 Vaccines Could Be Ethical Despite Risk of Severe Adverse Events.

Authors:  Nir Eyal
Journal:  Ethics Hum Res       Date:  2020-05-22
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  10 in total

1.  An ongoing science-society-ethics experiment: The human challenge trial debate in COVID-19 pandemic: The human challenge trial debate in COVID-19 pandemic.

Authors:  Sonia M R Vasconcelos; Angela Esher; Carmen Penido; Cleide Lima; Karina A Rocha; Maria Júlia M Antunes; Mariana D Ribeiro; Marlise Pedrotti
Journal:  EMBO Rep       Date:  2021-12-13       Impact factor: 8.807

2.  Research ethics and public trust in vaccines: the case of COVID-19 challenge trials.

Authors:  Nir Eyal
Journal:  J Med Ethics       Date:  2022-05-20       Impact factor: 5.926

Review 3.  Testing SARS-CoV-2 vaccine efficacy through deliberate natural viral exposure.

Authors:  Nir Eyal; Marc Lipsitch
Journal:  Clin Microbiol Infect       Date:  2021-01-06       Impact factor: 8.067

4.  Human challenge trials to assess the efficacy of currently approved COVID-19 vaccines against SARS-CoV-2 variants.

Authors:  Shan Su; Yiming Shao; Shibo Jiang
Journal:  Emerg Microbes Infect       Date:  2021-12       Impact factor: 7.163

5.  Strengthening and accelerating SARS-CoV-2 vaccine safety surveillance through registered pre-approval rollout after challenge tests.

Authors:  Nir Eyal; Tobias Gerhard; Brian L Strom
Journal:  Vaccine       Date:  2021-04-30       Impact factor: 3.641

6.  How to Test Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines Ethically Even After One Is Available.

Authors:  Nir Eyal; Marc Lipsitch
Journal:  Clin Infect Dis       Date:  2021-12-16       Impact factor: 9.079

7.  Controlled Human Infection to Speed Up SARS-CoV-2 Vaccine Development.

Authors:  Marc Baay; Pieter Neels
Journal:  Front Immunol       Date:  2021-03-12       Impact factor: 7.561

8.  Risk, benefit, and social value in Covid-19 human challenge studies: pandemic decision making in historical context.

Authors:  Mabel Rosenheck
Journal:  Monash Bioeth Rev       Date:  2022-06-15

9.  Pandemic vaccine testing: Combining conventional and challenge studies.

Authors:  Tobias Gerhard; Brian L Strom; Nir Eyal
Journal:  Pharmacoepidemiol Drug Saf       Date:  2022-03-31       Impact factor: 2.732

10.  Safety of COVID-19 vaccines.

Authors:  Qutaiba A Al Khames Aga; Waseem H Alkhaffaf; Tagreed H Hatem; Kawthar F Nassir; Yazan Batineh; Abdullah T Dahham; Dimah Shaban; Luma A Al Khames Aga; Manhal Y R Agha; Muaamar Traqchi
Journal:  J Med Virol       Date:  2021-07-28       Impact factor: 20.693
  10 in total

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