Literature DB >> 3312079

5-Methyltetrahydrohomofolate.

P J O'Dwyer1, B H Wagner, D F Hoth, B Leyland-Jones.   

Abstract

5-methyltetrahydrohomofolate was developed in the 1970's as an antifolate with the potential to overcome methotrexate resistance. This review summarizes the preclinical and clinical data which have accumulated to date. It is concluded that more recent, better characterized antifolates offer greater potential in achieving the goals for which this drug was introduced.

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Year:  1987        PMID： 3312079     DOI： 10.1007/BF00175290

Source DB:  PubMed          Journal:  Invest New Drugs        ISSN： 0167-6997            Impact factor:   3.850


  10 in total

1.  Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation.

Authors:  R M Hoffman; S J Jacobsen; R W Erbe
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

2.  Reversion to methionine independence by malignant rat and SV40-transformed human fibroblasts.

Authors:  R M Hoffman; S J Jacobsen; R W Erbe
Journal:  Biochem Biophys Res Commun       Date:  1978-05-15       Impact factor: 3.575

3.  Further evaluation of the antitumor activity of homofolate and its reduced derivatives against methotrexate-insensitive tumors.

Authors:  L C Mishra; J A Mead
Journal:  Chemotherapy       Date:  1972       Impact factor: 2.544

Review 4.  Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines.

Authors:  B Roth; C C Cheng
Journal:  Prog Med Chem       Date:  1982

Review 5.  Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.

Authors:  R M Hoffman
Journal:  Biochim Biophys Acta       Date:  1984

Review 6.  The clinical pharmacology of methotrexate.

Authors:  J H Schornagel; J G McVie
Journal:  Cancer Treat Rev       Date:  1983-03       Impact factor: 12.111

7.  Action of diastereoisomers of tetrahydrohomofolate on the growth of Lactobacillus casei.

Authors:  R L Kisliuk; Y Gaumont
Journal:  Ann N Y Acad Sci       Date:  1971-11-30       Impact factor: 5.691

8.  Disposition of 5-methyltetrahydrohomofolate in mice, dogs, and monkeys.

Authors:  S M El Dareer; K F Tillery; D L Hill
Journal:  Cancer Treat Rep       Date:  1979-02

9.  Clinical pharmacokinetics of 5-methyltetrahydrohomofolate.

Authors:  T L Loo; L Jiushi; K Lu; N Savaraj
Journal:  Cancer Res       Date:  1983-02       Impact factor: 12.701

10.  Disposition of 5-methyltetrahydrohomofolate and methotrexate in rats.

Authors:  S M El-Dareer; K F Tillery; D L Hill
Journal:  Cancer Treat Rep       Date:  1981 Jan-Feb
  10 in total

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