Literature DB >> 3311770

MK-801 powerfully protects against N-methyl aspartate neurotoxicity.

J Olney1, M Price, K S Salles, J Labruyere, G Frierdich.   

Abstract

Using the ex vivo chick embryo retina to study the efficacy of antagonists in blocking the excitotoxic effects of excitatory amino acid agonists, we previously identified phencyclidine as the most powerful known anti-excitotoxin. Here we show that MK-801 is 5 times more powerful than phencyclidine as an anti-excitotoxin, that its antagonism is specific for N-methyl-asparate toxicity, is non-competitive and does not entail inhibition of excitatory amino acid receptor binding.

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Year:  1987        PMID： 3311770     DOI： 10.1016/0014-2999(87)90552-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  15 in total

1.  In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor.

Authors:  H Ulrich; J E Ippolito; O R Pagán; V A Eterović; R M Hann; H Shi; J T Lis; M E Eldefrawi; G P Hess
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

2.  Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.

Authors:  J S Hahn; E Aizenman; S A Lipton
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

Review 3.  Ca2+ -permeable acid-sensing ion channels and ischemic brain injury.

Authors:  Z-G Xiong; X-P Chu; R P Simon
Journal:  J Membr Biol       Date:  2006-04-17       Impact factor: 1.843

4.  Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801.

Authors:  H Tsiang; P E Ceccaldi; A Ermine; B Lockhart; S Guillemer
Journal:  Antimicrob Agents Chemother       Date:  1991-03       Impact factor: 5.191

5.  Role of NMDA receptors in pentobarbital tolerance/dependence.

Authors:  S Oh; K Hoshi; I K Ho
Journal:  Neurochem Res       Date:  1997-07       Impact factor: 3.996

6.  The effect of the desglycinyl metabolite of remacemide hydrochloride (FPL 12495AA) and dizocilpine (MK-801) on endogenous amino acid release from mouse cortex.

Authors:  J Srinivasan; A Richens; J A Davies
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739

7.  Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat.

Authors:  J J Greer; J C Smith; J L Feldman
Journal:  J Physiol       Date:  1991-06       Impact factor: 5.182

8.  Intraventricular infusion of N-methyl-D-aspartate. 1. Acute blood-brain barrier consequences.

Authors:  W D Dietrich; O Alonso; M Halley; R Busto; M Y Globus
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

9.  Biologically active MK-801 and SKF-10,047 binding sites distinct from those in rat brain are expressed on human lung cancer cells.

Authors:  R Maneckjee; J D Minna
Journal:  Mol Biol Cell       Date:  1992-06       Impact factor: 4.138

10.  A behavioral model of excitotoxicity: retinal degeneration, loss of vision, and subsequent recovery after intraocular NMDA administration in adult rats.

Authors:  B A Sabel; J Sautter; T Stoehr; R Siliprandi
Journal:  Exp Brain Res       Date:  1995       Impact factor: 1.972
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