Literature DB >> 1674849

Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801.

H Tsiang1, P E Ceccaldi, A Ermine, B Lockhart, S Guillemer.   

Abstract

A noncompetitive N-methyl-D-aspartate (NMDA) antagonist, MK-801 (0.5 to 2.0 mM), inhibits rabies virus infection in rat primary cortical neurons, whereas the competitive NMDA antagonist AP5 has no effect. The results suggest that MK-801-mediated inhibition of rabies virus replication, although selective, is not operating through the high-affinity binding site mechanism.

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Year:  1991        PMID： 1674849      PMCID： PMC245052          DOI： 10.1128/AAC.35.3.572

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Non-competitive inhibition of GABA currents by phenothiazines in cultured chick spinal cord and rat hippocampal neurons.

Authors:  C F Zorumski; J Yang
Journal:  Neurosci Lett       Date:  1988-09-23       Impact factor: 3.046

2.  Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.

Authors:  A C Foster; R Gill; G N Woodruff
Journal:  J Neurosci       Date:  1988-12       Impact factor: 6.167

3.  Rabies pathogenesis.

Authors:  F A Murphy
Journal:  Arch Virol       Date:  1977       Impact factor: 2.574

4.  MK-801 protects the neonatal brain from hypoxic-ischemic damage.

Authors:  J W McDonald; F S Silverstein; M V Johnston
Journal:  Eur J Pharmacol       Date:  1987-08-21       Impact factor: 4.432

5.  Ketamine inhibits 45Ca influx and catecholamine secretion by inhibiting 22Na influx in cultured bovine adrenal medullary cells.

Authors:  H Takara; A Wada; M Arita; K Sumikawa; F Izumi
Journal:  Eur J Pharmacol       Date:  1986-06-17       Impact factor: 4.432

6.  Phencyclidine blocks two potassium currents in spinal neurons in cell culture.

Authors:  L G Aguayo; E X Albuquerque
Journal:  Brain Res       Date:  1987-12-08       Impact factor: 3.252

7.  Rabies virus infection of cultured rat sensory neurons.

Authors:  E Lycke; H Tsiang
Journal:  J Virol       Date:  1987-09       Impact factor: 5.103

8.  Excitatory amino acids and the basal ganglia: implications for the therapy of Parkinson's disease.

Authors:  T Klockgether; L Turski
Journal:  Trends Neurosci       Date:  1989-08       Impact factor: 13.837

9.  Non-competitive antagonists of N-methyl-D-aspartate receptors protect cortical and hippocampal cell cultures against glutamate neurotoxicity.

Authors:  G Rondouin; M J Drian; R Chicheportiche; J M Kamenka; A Privat
Journal:  Neurosci Lett       Date:  1988-08-31       Impact factor: 3.046

10.  Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.

Authors:  J T Greenamyre; J B Penney; C J D'Amato; A B Young
Journal:  J Neurochem       Date:  1987-02       Impact factor: 5.372
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  4 in total

Review 1.  Virus-neuron interaction: an experimental model.

Authors:  H Tsiang
Journal:  Cell Biol Toxicol       Date:  1992 Jul-Sep       Impact factor: 6.691

2.  Inhibition of rabies virus transcription in rat cortical neurons with the dissociative anesthetic ketamine.

Authors:  B P Lockhart; N Tordo; H Tsiang
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

3.  Rabies virus infection of primary neuronal cultures and adult mice: failure to demonstrate evidence of excitotoxicity.

Authors:  Simon C Weli; Courtney A Scott; Christopher A Ward; Alan C Jackson
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

4.  Rabies virus is not cytolytic for rat spinal motoneurons in vitro.

Authors:  Céline Guigoni; Patrice Coulon
Journal:  J Neurovirol       Date:  2002-08       Impact factor: 2.643
  4 in total

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