Soad A Mohamad1, Hesham Salem2, Heba A Yassin3, Heba F Mansour4. 1. Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt. 2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt. 3. Department of Pharmaceutics, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt. 4. Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
Abstract
OBJECTIVE: To formulate and assess bucco-adhesive films of propranolol hydrochloride for pediatric use. METHODS: Different films were formulated adopting mucin, polyvinyl alcohol, chitosan and carbopol. A drug/polymer compatibility study was conducted adopting differential scanning calorimetry and Fourier transform infrared spectroscopy. The prepared films were physically investigated for variation of weight, propranolol content, thickness, surface pH, proportion of moisture, folding endurance and mucoadhesion. In vitro drug release study and kinetic analysis of the corresponding data have been conducted. The optimized formulation was selected for a bioavailability study using albino rabbits and adopting a developed HPLC method. The pharmacokinetic parameters of the drug were calculated following administration of the optimized film and the corresponding marketed oral tablets to albino rabbits. KEY FINDING: The compatibility study revealed the absence of drug/polymer interaction. The film formulations had suitable mucoadhesive and mechanical properties. The optimized formulation exhibited reasonable drug release that followed Higuchi diffusion pattern. The calculated AUC0-8h presented an enhancement in the bioavailability of propranolol hydrochloride from the selected film formulation by 1.9 times relative to the marketed propranolol oral tablets. CONCLUSION: These findings support that propranolol hydrochloride bucco-adhesive film can be considered as a proper effective dosage form for pediatric delivery.
OBJECTIVE: To formulate and assess bucco-adhesive films of propranolol hydrochloride for pediatric use. METHODS: Different films were formulated adopting mucin, polyvinyl alcohol, chitosan and carbopol. A drug/polymer compatibility study was conducted adopting differential scanning calorimetry and Fourier transform infrared spectroscopy. The prepared films were physically investigated for variation of weight, propranolol content, thickness, surface pH, proportion of moisture, folding endurance and mucoadhesion. In vitro drug release study and kinetic analysis of the corresponding data have been conducted. The optimized formulation was selected for a bioavailability study using albino rabbits and adopting a developed HPLC method. The pharmacokinetic parameters of the drug were calculated following administration of the optimized film and the corresponding marketed oral tablets to albino rabbits. KEY FINDING: The compatibility study revealed the absence of drug/polymer interaction. The film formulations had suitable mucoadhesive and mechanical properties. The optimized formulation exhibited reasonable drug release that followed Higuchi diffusion pattern. The calculated AUC0-8h presented an enhancement in the bioavailability of propranolol hydrochloride from the selected film formulation by 1.9 times relative to the marketed propranolol oral tablets. CONCLUSION: These findings support that propranolol hydrochloride bucco-adhesive film can be considered as a proper effective dosage form for pediatric delivery.
Authors: Minesh M Patel; John D Smart; Thomas G Nevell; Richard J Ewen; Peter J Eaton; John Tsibouklis Journal: Biomacromolecules Date: 2003 Sep-Oct Impact factor: 6.988
Authors: Ni Zeng; Johanne Seguin; Pierre-Louis Destruel; Gilles Dumortier; Marc Maury; Hélène Dhotel; Michel Bessodes; Daniel Scherman; Nathalie Mignet; Vincent Boudy Journal: Int J Pharm Date: 2017-10-02 Impact factor: 5.875