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Literature DB >> 12959582

Mucin/poly(acrylic acid) interactions: a spectroscopic investigation of mucoadhesion.

Minesh M Patel¹, John D Smart, Thomas G Nevell, Richard J Ewen, Peter J Eaton, John Tsibouklis.

Abstract

Studies using infrared, (1)H and (13)C nuclear magnetic resonance, and X-ray photoelectron spectroscopies and differential scanning calorimetry support the hypothesis that hydrogen bonds, formed between the carboxylic acid functionality of the mucoadhesive material poly(acrylic acid) and the glycoprotein component of mucus, play a significant role in the process of mucoadhesion. There are fewer H-bonded interactions between the components than within the bulk of the pure mucoadhesive agent. The pH of the medium influences the structures of both the poly(acrylic acid) and the mucus, which, in turn, determine the nature and the extent of mucoadhesive interactions.

Entities: Chemical Gene

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Year: 2003 PMID： 12959582 DOI： 10.1021/bm034028p

Source DB: PubMed Journal: Biomacromolecules ISSN： 1525-7797 Impact factor: 6.988

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