| Literature DB >> 33107562 |
Caroline M Mitchell1, Sujatha Srinivasan2, Nanxun Ma3, Susan D Reed4, Michael C Wu3, Noah G Hoffman5, Daniel J Valint2, Sean Proll2, Tina L Fiedler2, Kathy J Agnew4, Katherine A Guthrie3, David N Fredricks2.
Abstract
The Nugent score is the reference standard for bacterial vaginosis (BV) diagnosis but has not been validated in postmenopausal women. We compared relative abundances from 16S ribosomal RNA gene sequencing of vaginal microbiota with Nugent score in cohorts of premenopausal (n = 220) and postmenopausal (n = 144) women. In premenopausal women, 33 taxa were significantly correlated with Nugent score, including the classic BV-associated taxa Gardnerella, Atopobium, Sneathia, Megasphaera, and Prevotella. In postmenopausal women, 11 taxa were significantly associated with Nugent score, including Prevotella but no other BV-associated genera. High Nugent scores should not be used to infer BV in postmenopausal women.Entities:
Keywords: bacterial vaginosis; menopause; vaginal microbiota; vaginitis
Mesh：
Substances：
Year: 2021 PMID： 33107562 PMCID： PMC8350750 DOI： 10.1093/infdis/jiaa675
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226