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Literature DB >> 33104961

Angiogenic Exosome-Derived microRNAs: Emerging Roles in Cardiovascular Disease.

Abstract

Angiogenesis is the process of growing endothelial capillary cells. Exosomes are extracellular vesicles that are rich in miRNAs. Studies have shown that exosomes can carry communication between cells and various tissues by delivering miRNAs to their target organs and cells. It has been repeatedly proven that miRNAs regulate the expression of growth factors and other proteins in endothelial cells through paracrine signalling and participate in the physiological and pathological processes of angiogenesis. In the diagnosis and treatment of diseases, exosome-derived microRNAs can play important roles as biomarkers and drug carriers. In this review, we introduce the characteristics of miRNAs and exosomes and their interactions. Then, we specifically summarize the exosome-derived miRNAs related to angiogenesis, and we discuss the potential uses of exosome-derived miRNAs for diagnosing and treating cardiovascular diseases. Graphical abstract.

Entities: Chemical

Keywords: Angiogenesis; Biomarkers; Cardiovascular diseases; Endothelial cells; Exosomes; Therapeutic targets; microRNAs

Mesh：

Substances：
MicroRNAs

Year: 2020 PMID： 33104961 DOI： 10.1007/s12265-020-10082-9

Source DB: PubMed Journal: J Cardiovasc Transl Res ISSN： 1937-5387 Impact factor: 4.132

94 in total

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