BACKGROUND: Since December 2016, the basic military training (BMT) facility for the Canadian Armed Forces (CAF) has experienced repeated outbreaks of Group A Streptococcus (GAS). In 2018, a voluntary mass antibiotic prophylaxis (MAP) program was implemented to interrupt GAS transmission among recruits. The objective of this study was to describe the epidemiology of three GAS outbreaks and a period of increased pharyngitis infections at the CAF BMT facility in Québec over a two-year span, and to detail the prevention and control measures implemented to mitigate the risk to recruit health. METHODS: Descriptive data were collected on invasive and severe GAS cases along with laboratory data including genotyping of throat swabs from recruits presenting with pharyngitis. A laboratory-based acute respiratory infection surveillance system was used to aid in monitoring and decision-making. Close contacts of recruits were assessed for asymptomatic GAS carriage and MAP adverse events surveillance was conducted. RESULTS: Three distinct GAS outbreaks occurred at the Canadian Forces Leadership and Recruit School totaling eight invasive (iGAS) and 13 severe (sGAS) cases over two years. All iGAS/sGAS cases, apart from one instructor, were among recruits. The predominant strain in all three outbreaks was type emm6.4. A total of 11,293 recruits received MAP (penicillin G benzathine or azithromycin) between March 7, 2018 and November 18, 2019. There were eight reported serious adverse events related to penicillin administration. CONCLUSION: The CAF BMT facility experienced three GAS outbreaks over the course of two years, and despite the use of enhanced hygiene measures, only MAP has been effective in quelling these outbreaks.
BACKGROUND: Since December 2016, the basic military training (BMT) facility for the Canadian Armed Forces (CAF) has experienced repeated outbreaks of Group A Streptococcus (GAS). In 2018, a voluntary mass antibiotic prophylaxis (MAP) program was implemented to interrupt GAS transmission among recruits. The objective of this study was to describe the epidemiology of three GAS outbreaks and a period of increased pharyngitis infections at the CAF BMT facility in Québec over a two-year span, and to detail the prevention and control measures implemented to mitigate the risk to recruit health. METHODS: Descriptive data were collected on invasive and severe GAS cases along with laboratory data including genotyping of throat swabs from recruits presenting with pharyngitis. A laboratory-based acute respiratory infection surveillance system was used to aid in monitoring and decision-making. Close contacts of recruits were assessed for asymptomatic GAS carriage and MAP adverse events surveillance was conducted. RESULTS: Three distinct GAS outbreaks occurred at the Canadian Forces Leadership and Recruit School totaling eight invasive (iGAS) and 13 severe (sGAS) cases over two years. All iGAS/sGAS cases, apart from one instructor, were among recruits. The predominant strain in all three outbreaks was type emm6.4. A total of 11,293 recruits received MAP (penicillin G benzathine or azithromycin) between March 7, 2018 and November 18, 2019. There were eight reported serious adverse events related to penicillin administration. CONCLUSION: The CAF BMT facility experienced three GAS outbreaks over the course of two years, and despite the use of enhanced hygiene measures, only MAP has been effective in quelling these outbreaks.
Entities:
Keywords:
Canada; Streptococcus pyogenes; infectious disease outbreaks; mass antibiotic prophylaxis; military recruits
Authors: Bryant J Webber; John W Kieffer; Brian K White; Anthony W Hawksworth; Paul C F Graf; Heather C Yun Journal: Prev Med Date: 2018-10-26 Impact factor: 4.018
Authors: H Dickinson; M Reacher; B Nazareth; H Eagle; D Fowler; A Underwood; M Chand; V Chalker; J Coelho; R Daniel; G Kapatai; A Al-Shabib; R Puleston Journal: J Hosp Infect Date: 2018-03-22 Impact factor: 3.926
Authors: G C Gray; D C McPhate; M Leinonen; G H Cassell; E P Deperalta; S D Putnam; J A Karcher; M H Sawyer; A Laurila; J D Connor Journal: Clin Infect Dis Date: 1998-01 Impact factor: 9.079
Authors: Sarah Teatero; Allison McGeer; Gregory J Tyrrell; Linda Hoang; Hanan Smadi; Marc-Christian Domingo; Paul N Levett; Michael Finkelstein; Ken Dewar; Agron Plevneshi; Taryn B T Athey; Jonathan B Gubbay; Michael R Mulvey; Irene Martin; Walter Demczuk; Nahuel Fittipaldi Journal: Open Forum Infect Dis Date: 2018-04-20 Impact factor: 3.835