Literature DB >> 3309950

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

M A Goldsmith1, A Weiss.   

Abstract

We have developed an approach for deriving and characterizing antigen-receptor (CD3/Ti) signal-transduction mutants. This strategy combines receptor-mediated growth inhibition and fluorescence-activated cell sorting with the Ca2+-indicator indo-1. Despite the expression of structurally normal CD3/Ti complexes, one such mutant (J.CaM1) fails to exhibit inositolphospholipid metabolism or Ca2+ mobilization in response to anti-CD3 or anti-Ti monoclonal antibodies and fails to produce lymphokines in response to these antibodies. Surprisingly, anti-Ti antibody retains its effectiveness as a stimulus for the down-regulation of CD3/Ti surface expression. These cells remain responsive to AIF-4, at least one anti-CD3 antibody, and some combinations of nonagonist anti-Ti and anti-CD3 antibodies. The mutation in J.CaM1 appears to lie in a proximal component of the signal-transduction apparatus.

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Year:  1987        PMID： 3309950      PMCID： PMC299188          DOI： 10.1073/pnas.84.19.6879

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

Review 1.  Structure, function, and serology of the T-cell antigen receptor complex.

Authors:  J P Allison; L L Lanier
Journal:  Annu Rev Immunol       Date:  1987       Impact factor: 28.527

2.  Investigation of early T cell activation: analysis of the effect of specific antigen, interleukin 2 and monoclonal antibodies on intracellular free calcium concentration.

Authors:  K O'Flynn; E D Zanders; J R Lamb; P C Beverley; D L Wallace; P E Tatham; W J Tax; D C Linch
Journal:  Eur J Immunol       Date:  1985-01       Impact factor: 5.532

3.  Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx.

Authors:  H C Oettgen; C Terhorst; L C Cantley; P M Rosoff
Journal:  Cell       Date:  1985-03       Impact factor: 41.582

4.  The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.

Authors:  J B Imboden; A Weiss; J D Stobo
Journal:  J Immunol       Date:  1985-02       Impact factor: 5.422

5.  Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

Authors:  A Weiss; J D Stobo
Journal:  J Exp Med       Date:  1984-11-01       Impact factor: 14.307

6.  A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Authors:  G Grynkiewicz; M Poenie; R Y Tsien
Journal:  J Biol Chem       Date:  1985-03-25       Impact factor: 5.157

7.  Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex.

Authors:  E L Reinherz; S Meuer; K A Fitzgerald; R E Hussey; H Levine; S F Schlossman
Journal:  Cell       Date:  1982-10       Impact factor: 41.582

8.  Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

Authors:  A Weiss; J Imboden; D Shoback; J Stobo
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

9.  Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.

Authors:  M J Weiss; J F Daley; J C Hodgdon; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

10.  Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

Authors:  J B Imboden; J D Stobo
Journal:  J Exp Med       Date:  1985-03-01       Impact factor: 14.307
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  42 in total

Review 1.  Genetic analysis of CD28 signaling.

Authors:  Tiffani A Greene; Virginia Smith Shapiro
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

Review 2.  Structure and function of the T cell antigen receptor.

Authors:  A Weiss
Journal:  J Clin Invest       Date:  1990-10       Impact factor: 14.808

Review 3.  The right team at the right time to go for a home run: tyrosine kinase activation by the TCR.

Authors:  Arthur Weiss
Journal:  Nat Immunol       Date:  2010-02       Impact factor: 25.606

4.  Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46.

Authors:  George Zahariadis; Melany J Wagner; Rosalyn C Doepker; Jessica M Maciejko; Carly M Crider; Keith R Jerome; James R Smiley
Journal:  J Virol       Date:  2008-04-16       Impact factor: 5.103

5.  Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.

Authors:  J Wong; D Straus; A C Chan
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

6.  L-selectin activates the Ras pathway via the tyrosine kinase p56lck.

Authors:  B Brenner; E Gulbins; K Schlottmann; U Koppenhoefer; G L Busch; B Walzog; M Steinhausen; K M Coggeshall; O Linderkamp; F Lang
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-24       Impact factor: 11.205

7.  Ligand-induced association between the T-cell antigen receptor and two glycoproteins.

Authors:  J D Fraser; M A Goldsmith; A Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

8.  The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.

Authors:  Manqing Li; Su Sien Ong; Bartek Rajwa; Vivian T Thieu; Robert L Geahlen; Marietta L Harrison
Journal:  Mol Cell Biol       Date:  2007-11-12       Impact factor: 4.272

9.  T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase.

Authors:  Anjali J de Souza; Jean S Oak; Ryan Jordanhazy; Rosemarie H DeKruyff; David A Fruman; Lawrence P Kane
Journal:  J Immunol       Date:  2008-05-15       Impact factor: 5.422

10.  Herpes simplex virus requires VP11/12 to induce phosphorylation of the activation loop tyrosine (Y394) of the Src family kinase Lck in T lymphocytes.

Authors:  Melany J Wagner; James R Smiley
Journal:  J Virol       Date:  2009-09-23       Impact factor: 5.103
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