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Literature DB >> 3871211

The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.

Abstract

A monoclonal antibody to the antigen-receptor on the T cell line Jurkat induces substantial increases in [Ca++]i. Ca++ ionophores can substitute for this antibody in activation by increasing [Ca++]i to levels comparable with those seen with the antigen-receptor antibody. Stimulation with either the antigen-receptor antibody or a Ca++ ionophore leads to the appearance of the same phosphoproteins. These results suggest that the antigen-receptor initiates T cell activation by increasing [Ca++]i.

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Year: 1985 PMID： 3871211

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

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Cited

57 in total

1. Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact.

Authors: D Schwartz; R C Wong; T Chatila; A Arnaout; R Miller; R Geha
Journal: J Clin Immunol Date: 1989-03 Impact factor: 8.317

2. Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

Authors: C H June; J A Ledbetter; P S Rabinovitch; P J Martin; P G Beatty; J A Hansen
Journal: J Clin Invest Date: 1986-04 Impact factor: 14.808

3. Mechanisms for induction of L-selectin loss from T lymphocytes by a cryptococcal polysaccharide, glucuronoxylomannan.

Authors: Z M Dong; L Jackson; J W Murphy
Journal: Infect Immun Date: 1999-01 Impact factor: 3.441

4. Calcium influx and intracellular calcium release in anti-CD3 antibody-stimulated and thapsigargin-treated human T lymphoblasts.

Authors: B Sarkadi; A Tordai; L Homolya; O Scharff; G Gárdos
Journal: J Membr Biol Date: 1991-07 Impact factor: 1.843

5. Failure of T cell receptor-anti-CD3 monoclonal antibody interaction in T cells from marrow recipients to induce increases in intracellular ionized calcium.

Authors: M Yamagami; P W McFadden; S M Koethe; V Ratanatharathorn; L G Lum
Journal: J Clin Invest Date: 1990-10 Impact factor: 14.808

The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.

1. Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact.

2. Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

3. Mechanisms for induction of L-selectin loss from T lymphocytes by a cryptococcal polysaccharide, glucuronoxylomannan.

4. Calcium influx and intracellular calcium release in anti-CD3 antibody-stimulated and thapsigargin-treated human T lymphoblasts.

5. Failure of T cell receptor-anti-CD3 monoclonal antibody interaction in T cells from marrow recipients to induce increases in intracellular ionized calcium.

6. Characterization of antigen receptor response elements within the interleukin-2 enhancer.

7. Cyclosporin A inhibits mitogen-activated but not phorbol ester-activated locomotion of human lymphocytes.

8. Impaired T-cell activation in patients with systemic lupus erythematosus.

9. The tetracycline derivative minocycline differentially affects cytokine production by monocytes and T lymphocytes.

10. Dimerization of translationally controlled tumor protein is essential for its cytokine-like activity.