| Literature DB >> 33098414 |
Katie J Sheehan1, Aicha Goubar1, Orouba Almilaji1, Finbarr C Martin1,2, Chris Potter2, Gareth D Jones2, Catherine Sackley1, Salma Ayis1.
Abstract
OBJECTIVE: To determine whether mobilisation timing was associated with the cumulative incidence of hospital discharge by 30 days after hip fracture surgery, accounting for potential confounders and the competing risk of in-hospital death.Entities:
Keywords: audit; competing event; early mobilisation; hip fracture; length of stay; older people
Mesh:
Year: 2021 PMID: 33098414 PMCID: PMC7936027 DOI: 10.1093/ageing/afaa204
Source DB: PubMed Journal: Age Ageing ISSN: 0002-0729 Impact factor: 10.668
Characteristics of 135,105 patients surgically treated for nonpathological first hip fracture overall and by timing of mobilisation
| All ( | Mobilisation day of or day after surgery ( | Mobilisation at least 2 days after surgery ( | ||
|---|---|---|---|---|
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|
|
| ||
| Age at admission (years) | 60–74 | 23,908 (17.7) | 19,957 (83.5) | 3,951 (16.5) |
| 75–84 | 47,557 (35.2) | 38,067 (80.0) | 9,490 (20.0) | |
| 85–94 | 55,758 (41.3) | 42,899 (76.9) | 12,859 (23.1) | |
| ≥95 | 7,640 (5.7) | 5,612 (73.5) | 2,028 (26.5) | |
| Missing | 242 (0.2) | 187 (77.3) | 55 (22.7) | |
| Sex | Women | 98,227 (72.7) | 78,041 (79.4) | 20,186 (20.6) |
| Men | 36,876 (27.3) | 28,680 (77.8) | 8,196 (22.2) | |
| Missing | 2 (0.0) | 1 (50.0) | 1 (50.0) | |
| Ethnicity | White | 95,471 (70.7) | 75,890 (79.5) | 19,581 (20.5) |
| Caribbean or African or any mixed Black background | 227 (0.2) | 149 (65.6) | 78 (34.4) | |
| Asian or Asian British or any mixed Asian background | 1,193 (0.9) | 914 (76.6) | 279 (23.4) | |
| Any other mixed background | 25 (0.0) | 19 (76.0) | 6 (24.0) | |
| Missing | 38,189 (28.3) | 29,750 (77.9) | 8,439 (22.1) | |
| Comorbidities*, | Heart failure or pulmonary oedema | 12,969 (9.6) | 9,165 (70.7) | 3,804 (29.3) |
| Chronic obstructive pulmonary disease | 17,360 (12.9) | 13,105 (75.5) | 4,255 (24.5) | |
| Ischaemic heart disease (acute) | 11,547 (8.6) | 8,638 (74.8) | 2,909 (25.2) | |
| Cardiac dysrhythmias | 26,692 (19.8) | 19,935 (74.7) | 6,757 (25.3) | |
| Ischaemic heart disease (chronic) | 20,148 (14.9) | 15,109 (75.0) | 5,039 (25.0) | |
| Hypertension | 65,505 (48.5) | 51,771 (79.0) | 13,734 (21.0) | |
| Hypotension | 10,292 (7.6) | 7,388 (71.8) | 2,904 (28.2) | |
| Diabetes with complication | 1,674 (1.2) | 1,248 (74.6) | 426 (25.4) | |
| Alzheimer’s or dementia | 35,077 (26.0) | 25,283 (72.1) | 9,794 (27.9) | |
| Depression | 9,659 (7.2) | 7,412 (76.7) | 2,247 (23.3) | |
| Delirium | 10,000 (7.4) | 7,178 (71.8) | 2,822 (28.2) | |
| ASA grade | I | 3,105 (2.3) | 2,820 (2.6) | 285 (1.0) |
| II | 36,636 (27.1) | 31,503 (29.5) | 5,133 (18.1) | |
| III | 74,803 (55.4) | 58,179 (54.5) | 16,624 (58.6) | |
| IV | 16,993 (12.6) | 11,412 (10.7) | 5,581 (19.7) | |
| V | 289 (0.2) | 168 (0.2) | 121 (0.4) | |
| Missing | 3,279 (2.4) | 2,640 (2.5) | 639 (2.3) | |
| Prefracture residence | Own home/sheltered housing | 107,972 (79.9) | 87,887 (81.4) | 20,085 (18.6) |
| Nursing care/residential care | 24,487 (18.1) | 17,043 (69.6) | 7,444 (30.4) | |
| Other | 2,625 (1.9) | 1,775 (67.6) | 850 (32.4) | |
| Missing | 21 (0.0) | 17 (81.0) | 4 (19.0) | |
| Prefracture mobility | Freely mobile without aids | 51,911 (38.4) | 44,021 (84.8) | 7,890 (15.2) |
| Mobile outdoors with one aid | 30,179 (22.3) | 24,281 (80.5) | 5,898 (19.5) | |
| Mobile outdoors with two aids or frame | 18,893 (14.0) | 14,617 (77.4) | 4,276 (22.6) | |
| Some indoor mobility but never goes outside without help | 30,834 (22.8) | 21,663 (70.3) | 9,171 (29.7) | |
| No functional mobility | 1,786 (1.3) | 1,071 (60.0) | 715 (40.0) | |
| Missing | 1,502 (1.1) | 1,069 (71.2) | 433 (28.8) | |
| Deprivation | Least deprived 10% | 10,050 (7.4) | 7,827 (77.9) | 2,223 (22.1) |
| Less deprived 10–20% | 9,876 (7.3) | 7,620 (77.2) | 2,256 (22.8) | |
| Less deprived 20–30% | 10,748 (8.0) | 8,310 (77.3) | 2,438 (22.7) | |
| Less deprived 30–40% | 11,533 (8.5) | 8,964 (77.7) | 2,569 (22.3) | |
| Less deprived 40–50% | 12,104 (9.0) | 9,502 (78.5) | 2,602 (21.5) | |
| More deprived 40–50% | 12,783 (9.5) | 10,047 (78.6) | 2,736 (21.4) | |
| More deprived 30–40% | 12,564 (9.3) | 9,915 (78.9) | 2,649 (21.1) | |
| More deprived 20–30% | 12,194 (9.0) | 9,710 (79.6) | 2,484 (20.4) | |
| More deprived 10–20% | 12,092 (9.0) | 9,694 (80.2) | 2,398 (19.8) | |
| Most deprived 10% | 11,440 (8.5) | 9,215 (80.6) | 2,225 (19.4) | |
| Missing | 19,721 (14.6) | 15,918 (80.7) | 3,803 (19.3) | |
| Fracture type | Intracapsular | 79,797 (59.1) | 63,596 (79.7) | 16,201 (20.3) |
| Intertrochanteric | 47,238 (35.0) | 37,170 (78.7) | 10,068 (21.3) | |
| Subtrochanteric | 8,010 (5.9) | 5,907 (73.7) | 2,103 (26.3) | |
| Missing | 60 (0.0) | 49 (81.7) | 11 (18.3) | |
| Surgery timing | Within target time of 36 h | 96,721 (71.6) | 77,211 (79.8) | 19,510 (20.2) |
| Not within target time | 29,977 (22.2) | 22,849 (76.2) | 7,128 (23.8) | |
| Missing | 8,407 (6.2) | 6,662 (79.2) | 1,745 (20.8) | |
| Procedure type | Internal fixation | 65,790 (48.7) | 52,069 (79.1) | 13,721 (20.9) |
| Hemiarthroplasty | 58,320 (43.2) | 44,983 (77.1) | 13,337 (22.9) | |
| Arthroplasty | 10,407 (7.7) | 9,246 (88.8) | 1,161 (11.2) | |
| Missing/other | 588 (0.4) | 424 (72.1) | 164 (27.9) | |
| Calendar year of surgery | 2014 | 31,680 (23.5) | 24,668 (77.9) | 7,012 (22.1) |
| 2015 | 54,208 (40.1) | 43,185 (79.7) | 11,023 (20.3) | |
| 2016 | 49,217 (36.4) | 38,869 (79.0) | 10,348 (21.0) | |
| Day of admission | Weekday | 91,065 (67.4) | 71,720 (78.8) | 19,345 (21.2) |
| Weekend | 41,884 (31.0) | 33,480 (79.9) | 8,404 (20.1) | |
| Missing | 2,156 (1.6) | 1,522 (70.6) | 634 (29.4) | |
| Hospital volume*, | Low | 33,909 (25.1) | 26,506 (78.2) | 7,403 (21.8) |
| Medium | 32,013 (23.7) | 25,748 (80.4) | 6,265 (19.6) | |
| High | 69,183 (51.2) | 54,468 (78.7) | 14,715 (21.3) |
Data are presented according to the categories used in regression analysis.
* P ≤ 0.001.
aDoes not include 18,831 without comorbidity data.
bI, normal healthy individual; II, mild systemic disease that does not limit activity; III, severe systemic disease that limits activity but is not incapacitating; IV, incapacitating systemic disease, which is constantly life threatening; V-moribund, not expected to survive 24 h with or without surgery.
cLow (less than first quartile), medium (second and third quartile) or high (fourth quartile) volume at admission based on the average annual number of surgeries at the admitting hospital.
dRehabilitation unit/acute hospital/already in hospital/this hospital site/other hospital site of this trust/other hospital trust, merged with ‘missing’ for regression analysis.
Figure 1Cumulative incidence of postoperative discharge and death by days after surgery among patients surgically treated for nonpathological first hip fracture.
Cumulative incidence of discharge by timing of mobilisation among 135,105 patients surgically treated for nonpathological first hip fracture
| Mobilisation timing | Number of patients | Number of deaths | Number of discharges | Discharge rate (95% CI) | 30-day CIF, % (95% CI) | Pepe–Mori test ( | Unadjusted OR of CIF (95% CI) | Adjusted OR of CIF (95% CI) |
|---|---|---|---|---|---|---|---|---|
| Mobilised 2 days or more after surgery | 28,383 | 2,549 | 12,032 | 27.0 (26.6–27.5) | 567 (559–574) | 1.00 | 1.00 | |
| Mobilised on the day of or day after surgery | 106,722 | 3,160 | 59,298 | 43.1 (42.8–43.5) | 753 (750–757) | <0.001 | 2.36 (2.29–2.43) | 2.08 |
CIF, cumulative incidence function; CI, confidence interval; OR, odds ratio.
aAt 30 days from surgery.
bAt 30 days from surgery.
cPer 1,000 patient–days.
dTwo-sample test compared with mobilised 2 days or more after surgery.
eAdjusted for age, sex, ethnicity, fracture type, calendar period of admission, timing of surgery, comorbidity, ASA grade, prefracture residence, prefracture mobility, procedure type, day of admission and hospital volume. CIF regression at inpatient days 3, 4, 6, 8, 12, 16, 20, 24 and 30.
fExcludes 50,959 patients with unknown information on adjustment variables. Analysis after imputation of adjustment variables is available in Supplementary File 3.
Figure 2Cumulative incidence function (CIF) of postoperative discharge by days after surgery among patients surgically treated for nonpathological first hip fracture by timing of mobilisation.
Figure 3Additional discharges per 1,000 surgeries (95% CI) in patients who mobilised early when compared with number of discharges in patients who mobilised late.