AIM:To study the genetic susceptibility of HLA-DQA1 alleles to duodenal ulcer in Wuhan Hans. METHODS: Seventy patients with duodenal ulcer and fifty healthy controls were examined for HLA-DQA1 genotypes.HLA-DQA1 typing was carried out by digesting the locus specific polymerase chain reaction amplified products with alleles specific restriction enzymes (PCR-RFLP), i.e.,Apal I, Bsaj- I, Hph I, Fok I, Mbo II and Mnl I. RESULTS: The allele frequencies of DQA10301 and DQA1-0102 in patients with duodenal ulcer were significantly higher and lower respectively than those in healthy controls (0.40 vs 0.20, P = 0.003, P(corret) = 0.024) and (0.05 vs 0.14, P = 0.012, but P(corret) > 0.05), respectively. CONCLUSION: DQA1(*)0301 is a susceptible gene for duodenal ulcer in Wuhan Hans, and there are immunogenetic differences in HLA-DQA1 locus between duodenal ulcer patients and healthy controls.
AIM:To study the genetic susceptibility of HLA-DQA1 alleles to duodenal ulcer in Wuhan Hans. METHODS: Seventy patients with duodenal ulcer and fifty healthy controls were examined for HLA-DQA1 genotypes.HLA-DQA1 typing was carried out by digesting the locus specific polymerase chain reaction amplified products with alleles specific restriction enzymes (PCR-RFLP), i.e.,Apal I, Bsaj- I, Hph I, Fok I, Mbo II and Mnl I. RESULTS: The allele frequencies of DQA10301 and DQA1-0102 in patients with duodenal ulcer were significantly higher and lower respectively than those in healthy controls (0.40 vs 0.20, P = 0.003, P(corret) = 0.024) and (0.05 vs 0.14, P = 0.012, but P(corret) > 0.05), respectively. CONCLUSION: DQA1(*)0301 is a susceptible gene for duodenal ulcer in Wuhan Hans, and there are immunogenetic differences in HLA-DQA1 locus between duodenal ulcerpatients and healthy controls.
Authors: R Negrini; L Lisato; I Zanella; L Cavazzini; S Gullini; V Villanacci; C Poiesi; A Albertini; S Ghielmi Journal: Gastroenterology Date: 1991-08 Impact factor: 22.682
Authors: P Gionchetti; D Vaira; M Campieri; J Holton; M Menegatti; A Belluzzi; E Bertinelli; M Ferretti; C Brignola; M Miglioli Journal: Am J Gastroenterol Date: 1994-06 Impact factor: 10.864
Authors: F De Lazzari; O Mancin; M Plebani; C Venturi; G Battaglia; F Vianello; E A Galliani; F Di Mario; R Naccarato Journal: Ital J Gastroenterol Date: 1994 Jan-Feb
Authors: W S Ji; J L Hu; J W Qiu; B R Pan; D R Peng; B L Shi; S J Zhou; K C Wu; D M Fan Journal: World J Gastroenterol Date: 2001-12 Impact factor: 5.742