Literature DB >> 33096015

Serial cryoFIB/SEM Reveals Cytoarchitectural Disruptions in Leigh Syndrome Patient Cells.

Yanan Zhu1, Dapeng Sun2, Andreas Schertel3, Jiying Ning2, Xiaofeng Fu2, Pam Pam Gwo4, Alan M Watson5, Laura C Zanetti-Domingues6, Marisa L Martin-Fernandez6, Zachary Freyberg7, Peijun Zhang8.   

Abstract

The advancement of serial cryoFIB/SEM offers an opportunity to study large volumes of near-native, fully hydrated frozen cells and tissues at voxel sizes of 10 nm and below. We explored this capability for pathologic characterization of vitrified human patient cells by developing and optimizing a serial cryoFIB/SEM volume imaging workflow. We demonstrate profound disruption of subcellular architecture in primary fibroblasts from a Leigh syndrome patient harboring a disease-causing mutation in USMG5 protein responsible for impaired mitochondrial energy production.
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  CryoFIB/SEM; CryoSEM; Leigh syndrome; USMG5; block face; mitochondria disease; volume imaging

Year:  2020        PMID： 33096015      PMCID： PMC7802768          DOI： 10.1016/j.str.2020.10.003

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  27 in total

Review 1.  Leigh syndrome: neuropathology and pathogenesis.

Authors:  Nicole J Lake; Matthew J Bird; Pirjo Isohanni; Anders Paetau
Journal:  J Neuropathol Exp Neurol       Date:  2015-06       Impact factor: 3.685

Review 2.  Volume microscopy in biology: FIB-SEM tomography.

Authors:  Caroline Kizilyaprak; York-Dieter Stierhof; Bruno M Humbel
Journal:  Tissue Cell       Date:  2018-09-26       Impact factor: 2.466

3.  Calcium transport into the cells of the sea urchin larva in relation to spicule formation.

Authors:  Netta Vidavsky; Sefi Addadi; Andreas Schertel; David Ben-Ezra; Muki Shpigel; Lia Addadi; Steve Weiner
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-24       Impact factor: 11.205

Review 4.  Correlative fluorescence and electron microscopy.

Authors:  Randall T Schirra; Peijun Zhang
Journal:  Curr Protoc Cytom       Date:  2014-10-01

5.  USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis.

Authors:  Emanuele Barca; Rebecca D Ganetzky; Prasanth Potluri; Marti Juanola-Falgarona; Xiaowu Gai; Dong Li; Chaim Jalas; Yoel Hirsch; Valentina Emmanuele; Saba Tadesse; Marcello Ziosi; Hasan O Akman; Wendy K Chung; Kurenai Tanji; Elizabeth M McCormick; Emily Place; Mark Consugar; Eric A Pierce; Hakon Hakonarson; Douglas C Wallace; Michio Hirano; Marni J Falk
Journal:  Hum Mol Genet       Date:  2018-10-01       Impact factor: 6.150

6.  3D structure determination of native mammalian cells using cryo-FIB and cryo-electron tomography.

Authors:  Ke Wang; Korrinn Strunk; Gongpu Zhao; Jennifer L Gray; Peijun Zhang
Journal:  J Struct Biol       Date:  2012-07-14       Impact factor: 2.867

7.  TrakEM2 software for neural circuit reconstruction.

Authors:  Albert Cardona; Stephan Saalfeld; Johannes Schindelin; Ignacio Arganda-Carreras; Stephan Preibisch; Mark Longair; Pavel Tomancak; Volker Hartenstein; Rodney J Douglas
Journal:  PLoS One       Date:  2012-06-19       Impact factor: 3.240

8.  A meta-analysis and systematic review of Leigh syndrome: clinical manifestations, respiratory chain enzyme complex deficiency, and gene mutations.

Authors:  Xueli Chang; Yaxin Wu; Jie Zhou; Huaxing Meng; Wei Zhang; Junhong Guo
Journal:  Medicine (Baltimore)       Date:  2020-01       Impact factor: 1.889

Review 9.  Cryo-electron tomography: the challenge of doing structural biology in situ.

Authors:  Vladan Lučič; Alexander Rigort; Wolfgang Baumeister
Journal:  J Cell Biol       Date:  2013-08-05       Impact factor: 10.539

10.  Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography.

Authors:  Stephanie E Siegmund; Robert Grassucci; Stephen D Carter; Emanuele Barca; Zachary J Farino; Martí Juanola-Falgarona; Peijun Zhang; Kurenai Tanji; Michio Hirano; Eric A Schon; Joachim Frank; Zachary Freyberg
Journal:  iScience       Date:  2018-07-20
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  7 in total

1.  A modular platform for automated cryo-FIB workflows.

Authors:  Sven Klumpe; Herman Kh Fung; Sara K Goetz; Ievgeniia Zagoriy; Bernhard Hampoelz; Xiaojie Zhang; Philipp S Erdmann; Janina Baumbach; Christoph W Müller; Martin Beck; Jürgen M Plitzko; Julia Mahamid
Journal:  Elife       Date:  2021-12-24       Impact factor: 8.140

2.  Correlative Multi-scale Cryo-imaging Unveils SARS-CoV-2 Assembly and Egress.

Authors:  Peijun Zhang; Luiza Mendonca; Andrew Howe; James Gilchrist; Dapeng Sun; Michael Knight; Laura Zanetti-Domingues; Benji Bateman; Anna-Sophia Krebs; Long Chen; Julika Radecke; Yuewen Sheng; Vivian Li; Tao Ni; Ilias Kounatidis; Mohamed Koronfel; Marta Szynkiewicz; Maria Harkiolaki; Marisa Martin-Fernandez; William James
Journal:  Res Sq       Date:  2021-01-19

3.  Super-resolution confocal cryo-CLEM with cryo-FIB milling for in situ imaging of Deinococcus radiodurans.

Authors:  Danielle L Sexton; Steffen Burgold; Andreas Schertel; Elitza I Tocheva
Journal:  Curr Res Struct Biol       Date:  2021-12-13

4.  CorRelator: Interactive software for real-time high precision cryo-correlative light and electron microscopy.

Authors:  Jie E Yang; Matthew R Larson; Bryan S Sibert; Samantha Shrum; Elizabeth R Wright
Journal:  J Struct Biol       Date:  2021-02-18       Impact factor: 3.234

5.  Structure and activity of particulate methane monooxygenase arrays in methanotrophs.

Authors:  Yanan Zhu; Christopher W Koo; C Keith Cassidy; Matthew C Spink; Tao Ni; Laura C Zanetti-Domingues; Benji Bateman; Marisa L Martin-Fernandez; Juan Shen; Yuewen Sheng; Yun Song; Zhengyi Yang; Amy C Rosenzweig; Peijun Zhang
Journal:  Nat Commun       Date:  2022-09-05       Impact factor: 17.694

6.  Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress.

Authors:  Luiza Mendonça; Andrew Howe; James B Gilchrist; Yuewen Sheng; Dapeng Sun; Michael L Knight; Laura C Zanetti-Domingues; Benji Bateman; Anna-Sophia Krebs; Long Chen; Julika Radecke; Vivian D Li; Tao Ni; Ilias Kounatidis; Mohamed A Koronfel; Marta Szynkiewicz; Maria Harkiolaki; Marisa L Martin-Fernandez; William James; Peijun Zhang
Journal:  Nat Commun       Date:  2021-07-30       Impact factor: 17.694

Review 7.  Structural Analysis of Retrovirus Assembly and Maturation.

Authors:  Anna-Sophia Krebs; Luiza M Mendonça; Peijun Zhang
Journal:  Viruses       Date:  2021-12-29       Impact factor: 5.048
  7 in total

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